BLOOD VITAMIN AND TRACE-METAL LEVELS IN EPIDERMOLYSIS BULLOSA
BLOOD VITAMIN AND TRACE-METAL LEVELS IN EPIDERMOLYSIS BULLOSA
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DOI：
10.1001/archderm.125.3.374
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发表时间：
1989-03-01
影响因子：
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通讯作者：
JOHNSON, L
中科院分区：
文献类型：
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作者：
FINE, JD;TAMURA, T;JOHNSON, L
本文分析了73例遗传性大疱性表皮病（EB）患者血浆或红细胞中10种营养素（维生素A、C、B12、B6、叶酸、硫胺素、核黄素、锌、铜、铁）的水平。虽然每种营养素的平均水平在其正常范围内，但个别EB亚组中所选营养素的水平不足。值得注意的异常包括血浆铁和锌（在交界性EB和隐性营养不良性EB中）、维生素C（主要在单纯性EB中）、维生素A（在交界性和隐性营养不良性EB中）、维生素B12（主要在单纯性EB中）和维生素B6（特别是在隐性营养不良性EB中）水平低。然而，除了交界性和隐性营养不良性EB的血浆铁和锌水平较低外，任何EB亚群中只有少数患者的大多数其他营养素水平较低，并且仅与选定的营养素可能与吸收不良存在明显相关性。
Plasma or erythrocyte levels of ten nutrients (vitamins A, C, B12, and B6; folate; thiamine; riboflavin; zinc; copper; iron) were assayed in 73 patients with various forms of inherited epidermolysis bullosa (EB). Whereas the mean level for each nutrient was within its normal range, deficient levels noted in individuals EB subsets for selected nutrients. Notable abnormalities included low levels of plasma iron and zinc (in junctional EB and recessive dystrophic EB), vitamin C (primarily in EB simplex), vitamin A (in junctional and recessive dystrophic EB), vitamin B12 (primarily in EB simplex), and vitamin B6 (especially in recessive dystrophic EB). With the exception of low plasma iron and zinc levels in junctional and recessive dystrophic EB, however, only a minority of patients in any of the EB subsets had low levels of most of the other nutrients, and an apparent correlation with malabsorption was possible with only selected nutrients.