Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene.
Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene.
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DOI：
10.15288/jsa.2000.61.13
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
T. Wall;S. M. Horn;M. Johnson;T. Smith;L. Carr
中科院分区：
文献类型：
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作者：
T. Wall;S. M. Horn;M. Johnson;T. Smith;L. Carr
目的 并非所有人都会经历宿醉，并且宿醉是否会导致酗酒尚不清楚。亚洲血统的人群可能有助于了解宿醉在酒精使用障碍病因学中的作用。某些亚洲人的饮酒率和酗酒率较低，这一发现与乙醛脱氢酶 (ALDH2) 基因突变有关。与没有这种突变的亚洲人相比，携带 ALDH2*2 等位基因的亚洲人饮酒较少，酗酒的可能性也较小。摄入酒精后，它们对酒精表现出更强烈的反应，并产生更高水平的代谢物乙醛。这项研究评估了 ALDH2 基因变异的亚裔美国人的宿醉症状。方法 询问中国、日本和韩国血统的男性和女性 (N = 140) 的饮酒史，并采集血液样本进行 ALDH2 基因座基因分型。受试者使用李克特式量表来评估其宿醉的严重程度，并完成了包含 13 项的宿醉量表，以评估过去 6 个月内宿醉症状的频率。结果 排除戒酒者 (n = 17) 并控制性别和近期饮酒史的影响后，ALDH2 基因型在估计的宿醉评分严重程度方面产生了显着的额外变异性，与源自宿醉量表的五项分量表评分具有相似但不显着的趋势。结论 这些结果表明，携带 ALDH2*2 等位基因的亚裔美国人可能会经历更严重的宿醉，这可能在一定程度上有助于防止该人群出现过度饮酒或酗酒问题。
OBJECTIVE Hangovers are not experienced by all people and whether they contribute to the development of alcoholism is unclear. One population that might provide some insight into the role of hangover in the etiology of alcohol use disorders is that of individuals of Asian heritage. Certain Asians have lower rates of alcohol use and alcoholism, findings associated with a mutation in the aldehyde dehydrogenase (ALDH2) gene. Asians with ALDH2*2 alleles drink less and are less likely to be alcoholic than Asians without this mutation. Following alcohol ingestion, they exhibit more intense reactions to alcohol and generate higher levels of the metabolite acetaldehyde. This study evaluated hangover symptoms in Asian Americans with variations in the ALDH2 gene. METHOD Men and women of Chinese, Japanese and Korean heritage (N = 140) were asked about their drinking history and a blood sample was collected for genotyping at the ALDH2 locus. Subjects used a Likert-type scale to estimate their severity of hangover and completed a 13-item hangover scale assessing the frequency of hangover symptoms during the previous 6 months. RESULTS With abstainers (n = 17) excluded and with the effects of gender and recent drinking history controlled, ALDH2 genotype accounted for a significant amount of additional variability in the estimated severity of hangover score with a similar, but nonsignificant, trend for a five-item subscale score derived from the hangover scale. CONCLUSIONS These results suggest that Asian Americans with ALDH2*2 alleles may experience more severe hangovers that may contribute, in part, to protection against the development of excessive or problematic drinking in this population.