ANTIBIOTICS IN YERSINIA-ENTEROCOLITICA INFECTIONS
ANTIBIOTICS IN YERSINIA-ENTEROCOLITICA INFECTIONS
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DOI：
10.1093/jac/20.1.123
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发表时间：
1987-07-01
影响因子：
5.2
通讯作者：
HOOGKAMPKORSTANJE, JAA
中科院分区：
文献类型：
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作者：
HOOGKAMPKORSTANJE, JAA
进行了一项前瞻性研究来评估小肠结肠炎耶尔森菌感染患者的发病率、病程、治疗效果和结果。总共对 189 名患者进行了随访：62.5% 患有肠道疾病。 20.6% 为肠系膜外形式，23.2% 为关节炎和结节性红斑。肠系膜外型的主要表现是淋巴结肿大、高烧、体重减轻、败血综合征和肝炎。 10% 的分离株 (135) 对阿莫西林 (4 mg/l) 敏感，38% 对头孢拉定 (8 mg/l) 敏感，82% 对多西环素 (4 mg/l) 敏感，83% 对氯霉素 (4 mg/l) 敏感，85% 对甲氧苄啶 (1 mg/l) 敏感，87% 对头孢呋辛 (8 mg/l) 敏感，92% 对头孢呋辛 (8 mg/l) 敏感，92% 对头孢呋辛 (8 mg/l) 敏感。哌拉西林 (16 mg/l)、99% 庆大霉素 (1 mg/l) 和 100% 头孢噻肟 (4 mg/l)、全氟沙星 (0.12 mg/l)、氧氟沙星 (0.06 mg/l) 和环丙沙星 (0.016 mg/l)。大多数肠炎患者无需抗生素治疗即可康复。抗生素治疗对肠炎的持续时间没有显着影响。 85 例患者接受治疗，其中 46 例为肠内型，39 例为肠系膜外型。对复方新诺明的临床反应率为 71%，对多西环素的临床反应率为 75%。头孢呋辛、头孢他啶、头孢哌酮、哌拉西林和庆大霉素在八个疗程中有七个失败。三名接受环丙沙星治疗的患者反应良好。喹诺酮类药物在耶尔森氏菌病中的作用需要进一步关注。
A prospective study was undertaken to evaluate the incidence, course, effects of treatment and outcome of patients with Yersinia enterocolitica infections. A total of 189 patients were followed: 62.5% had enteric forms of illness. 20.6% extramesenteric forms, 23.2% arthritis and erythema nodosum. Lymphadenopathy with high fever and weight loss, a septic syndrome and hepatitis were predominant manifestations of the extramesenteric form. Ten per cent of the isolates (135) were susceptible to amoxycillin (4 mg/l), 38% to cephradine (8 mg/l), 82% to doxycycline (4 mg/l), 83% to chloramphenicol (4 mg/l), 85% to trimethoprim (1 mg l), 87% to cefuroxime (8 mg/l), 92% to piperacillin (16 mg/l), 99% to gentamicin (1 mg/l) and 100% to cefotaxime (4 mg/l), perfloxacin (0.12 mg/l), ofloxacin (0.06 mg/l) and ciprofloxacin (0.016 mg/l). The majority of the patients with enteritis recovered without antibiotic therapy. The duration of enteritis was not significantly influenced by antibiotic treatment. Eighty five patients, 46 with enteric and 39 with extramesenteric forms were treated. The clinical response to co-trimoxazole was 71%, and to doxycycline 75%. Cefuroxime, ceftazidime, cefoperazone, piperacillin and gentamicin failed in seven of eight courses. Three patients treated with ciprofloxacin responded well. The role of quinolones in yersiniosis needs further attention.