CARCINOGENICITY EXAMINATION OF QUERCETIN AND RUTIN IN ACI RATS
CARCINOGENICITY EXAMINATION OF QUERCETIN AND RUTIN IN ACI RATS
复制标题
DOI：
10.1016/0304-3835(81)90081-1
复制
发表时间：
1981-01-01
期刊：
影响因子：
9.7
通讯作者：
NATORI, S
中科院分区：
文献类型：
--
作者：
HIRONO, I;UENO, I;NATORI, S
以近交系ACI大鼠为实验动物，检测了槲皮素和芦丁的致癌性。以1%或5%的槲皮素或5%的芦丁或10%的槲皮素+10%的芦丁分别饲喂大鼠540天和850天。对照组大鼠按正常基础饲料喂养。实验组中发现的大多数肿瘤也在相应的对照组中发现。实验组和对照组的肿瘤发生率差异无统计学意义(P>；0.05)。槲皮素和芦丁对ACI大鼠无致癌作用。
Carcinogenicity of quercetin and rutin were examined in inbred ACI strain rats. Rats were given a diet containing 1 or 5% quercetin or 5% rutin for 540 days, or 10% quercetin and 10% rutin for 850 days. Rats in control groups were fed a normal basal diet. Most tumors found in experimental groups were also found in the corresponding control groups. There was no significant difference between the incidence of tumors in the experimental or control groups (P > 0.05). Quercetin and rutin were not shown to be carcinogenic to ACI rats.