Dietary ω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis
Dietary ω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis
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DOI：
10.1001/jamaneurol.2014.1214
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发表时间：
2014-09-01
期刊：
影响因子：
29
通讯作者：
Ascherio, Alberto
中科院分区：
文献类型：
--
作者：
Fitzgerald, Kathryn C.;O'Reilly, EIlis J.;Ascherio, Alberto
肌萎缩侧索硬化症(ALS)是一种严重的进行性疾病，无法预防或治愈。饮食衍生的长链多不饱和脂肪酸(PUFAs)结合在脑脂类中，调节氧化和炎症过程，从而可能影响ALS的风险和进展。目的检查omega-6和omega-3 PUFA摄入与ALS风险的关系。设计、设置和参与者基于5个前瞻性队列的1002 082名参与者(479 114名女性和522 968名男性)的纵向分析：国家卫生研究院-AARP饮食和健康研究、癌症预防研究II营养队列、卫生专业人员后续研究、多种族队列研究和护士健康研究。通过为每个队列制定或修改食物频率问卷来评估饮食。参与者被归类为摄入能量调整的饮食变量的队列特定的五分之一。MAIN结果和测量队列特定的多变量调整的ALS发病率或死亡的风险比(RR)通过COX比例风险回归估计，并使用随机效果方法合并。结果在随访期间，总共记录了995例ALS病例。摄入更多的omega-3多不饱和脂肪酸与ALS风险降低相关。从最高到最低五分之一的合并多变量调整RR为0.66(95%可信区间为0.53-0.81；趋势为P<；.001)。A-亚麻酸(相对危险度，0.73；95%可信区间，0.59-0.89；趋势为P=.003)和海洋omega-3多不饱和脂肪酸(相对危险度，0.84；95%可信区间，0.65-1.08；趋势为P=0.03)的消费促成了这种反向关联。摄入omega-6多不饱和脂肪酸与肌萎缩侧索硬化症的风险无关。结论建议并适当食用富含omega-3多不饱和脂肪酸的食物有助于预防或延迟肌萎缩侧索硬化症的发病。
IMPORTANCE Amyotrophic lateral sclerosis (ALS) is a severe progressive disease that cannot be prevented or cured. Diet-derived long-chain polyunsaturated fatty acids (PUFAs) are incorporated in brain lipids and modulate oxidative and inflammatory processes and could thus affect ALS risk and progression.OBJECTIVE To examine the association between omega-6 and omega-3 PUFA consumption and ALS risk.DESIGN, SETTING, AND PARTICIPANTS Longitudinal analyses based on 1 002 082 participants (479 114 women and 522 968 men) in 5 prospective cohorts: the National Institutes of Health-AARP Diet and Health Study, the Cancer Prevention Study II Nutrition Cohort, the Health Professionals Follow-up Study, the Multiethnic Cohort Study, and the Nurses' Health Study. Diet was assessed via food frequency questionnaire developed or modified for each cohort. Participants were categorized into cohort-specific quintiles of intake of energy-adjusted dietary variables.MAIN OUTCOMES AND MEASURES Cohort-specific multivariable-adjusted risk ratios (RRs) of ALS incidence or death estimated by Cox proportional hazards regression and pooled using random-effects methods.RESULTS A total of 995 ALS cases were documented during the follow-up. A greater omega-3 PUFA intake was associated with a reduced risk for ALS. The pooled, multivariable-adjusted RR for the highest to the lowest quintile was 0.66 (95% CI, 0.53-0.81; P < .001 for trend). Consumption of both a-linolenic acid (RR, 0.73; 95% CI, 0.59-0.89; P = .003 for trend) and marine omega-3 PUFAs (RR, 0.84; 95% CI, 0.65-1.08; P = .03 for trend) contributed to this inverse association. Intakes of omega-6 PUFA were not associated with ALS risk.CONCLUSIONS AND RELEVANCE Consumption of foods high in omega-3 PUFAs may help prevent or delay the onset of ALS.