TYRPHOSTINS AS MOLECULAR TOOLS AND POTENTIAL ANTIPROLIFERATIVE DRUGS
TYRPHOSTINS AS MOLECULAR TOOLS AND POTENTIAL ANTIPROLIFERATIVE DRUGS
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DOI：
10.1016/0165-6147(91)90538-4
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发表时间：
1991-05-01
影响因子：
13.8
通讯作者：
GILON, C
中科院分区：
文献类型：
--
作者：
LEVITZKI, A;GILON, C
蛋白酪氨酸激酶(PTKs)在正常细胞分裂和异常细胞增殖中起着关键作用。PTK活性增强与增殖性疾病如癌症、动脉粥样硬化有关，在乳腺癌和卵巢癌中可能与银屑病3：E有关。erb-B2/neu癌基因的过度表达与疾病严重程度和预后不良相关。
Protein tyrosine kinases (PTKs) play a key role in normal cell division and abnormal cell proliferation. Enhanced PTK activity has been associated with proliferative diseases such as cancers*, atherosclerosis* and, probably, with psoriasis3: e In mammary carcinoma4 and ovarian carcinoma4 overexpression of the erb-B2/neu oncogene correlates with severity of disease and poor prognosis.