Evolutionary history of the 11p15 human mucin gene family
Evolutionary history of the 11p15 human mucin gene family
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DOI：
10.1007/pl00006276
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发表时间：
1998-01-01
影响因子：
3.9
通讯作者：
Laine, A
中科院分区：
文献类型：
--
作者：
Desseyn, JL;Buisine, MP;Laine, A
四种人类粘蛋白基因MUC 6、MUC 2、MUC 5AC和MUC 5 B位于染色体11p15.5。已经证明，三种粘蛋白MUC 2、MUC 5AC和MUC 5 B含有几个108个氨基酸残基的Cys亚结构域。相反，关于MUC 6的信息很少。这些Cys-亚结构域含有10个具有高度保守位置的半胱氨酸残基。我们在这里提出了一个连贯的可能的进化历史，这个人类基因家族的比较后，这些Cys-亚结构域的核苷酸序列。三个MUC基因座MUC 2、MUC 5AC和MUC 5 B可能通过两个连续的重复从共同的祖先基因进化而来。此外，我们可以假设MUC 5AC和MUC 5 B以协同的方式进化，而MUC 2单独进化。
The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. In contrast, little information is available concerning MUC6. These Cys-subdomains contain 10 cysteine residues that have a highly conserved position. We present here a coherent probable evolutionary history of this human gene family after comparison of the nucleotide sequences of these Cys-subdomains. The three MUC loci MUC2, MUC5AC, and MUC5B may have evolved from a common ancestral gene by two successive duplications. Moreover, we can postulate that MUC5AC and MUC5B have evolved in a concerted manner, while MUC2 has evolved separately.