Nanoparticle Formulations in Pulmonary Drug Delivery
Nanoparticle Formulations in Pulmonary Drug Delivery
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DOI：
10.1002/med.20140
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发表时间：
2009-01-01
影响因子：
13.3
通讯作者：
Berkland, Cory J.
中科院分区：
文献类型：
--
作者：
Bailey, Mark M.;Berkland, Cory J.
纳米技术的出现重新点燃了人们对肺部作为全身和局部治疗的主要药物输送途径的兴趣。肺的大表面积和最小的阻碍进入肺周围的障碍使这个器官成为各种治疗干预的合适入口。纳米颗粒为分散液滴剂型（如计量吸入器和雾化器）和干粉剂型提供了新的剂型选择。纳米颗粒制剂比传统剂型具有许多优点，例如增强的溶解特性和细胞内药物传递的潜力。具体来说，纯药物纳米颗粒、聚合纳米颗粒、多电解质复合物和载药脂质体在将药物输送到肺部和通过肺部方面提供了一些令人鼓舞的结果。人们也在研究制造纳米颗粒的方法，这些纳米颗粒的特性适合改善周围肺的通路。传统的技术，如喷雾干燥和研磨，以及最近在超临界流体萃取、沉淀和溶剂萃取方面的进展，已被用于生产肺输送的纳米颗粒配方。在这里，根据生产配方的实际障碍和这些材料可能的毒理学效应，比较了纳米颗粒配方的好处和目前的进展。(C) 2008 Wiley期刊有限公司医学研究，29,No. 1, 196-212, 2009
The advent of nanotechnology has reignited interest in the lungs as a major route of drug delivery for both systemic and local treatments. The large surface area of the lungs and the minimal barriers impeding access to the lung periphery make this organ a suitable portal for a variety of therapeutic interventions. Nanoparticles provide new formulation options for both dispersed liquid droplet dosage forms such as metered dose inhalers and nebulizers, and dry powder formulations. Nanoparticle formulations have many advantages over traditional dosage forms, such as enhanced dissolution properties and the potential for intracellular drug delivery. Specifically, pure drug nanoparticles, polymeric nanoparticles, polyelectrolyte complexes, and drug-loaded liposomes offer some encouraging results for delivering drugs to and through the lungs. Methods are also being investigated to produce nanoparticles with properties suitable for improving access to the peripheral lung. Traditional techniques such as spray drying and grinding, and more recent advances in supercritical fluid extraction, precipitation, and solvent extraction have been employed to produce nanoparticle formulations for pulmonary delivery. Here, the benefits of nanoparticle formulations and current progress are compared in light of the practical encumbrances of producing formulations, and possible toxicological effects of these materials. (C) 2008 Wiley Periodicals, Inc. Med Res Rev, 29, No. 1, 196-212, 2009