Acromegaly associated with a bronchial carcinoid tumor: evidence for ectopic production of growth hormone-releasing activity.
Acromegaly associated with a bronchial carcinoid tumor: evidence for ectopic production of growth hormone-releasing activity.
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与支气管类癌相关的肢端肥大症：生长激素释放活性异位产生的证据。
DOI：
10.1210/jcem-48-1-66
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
L. A. Frohman
中科院分区：
文献类型：
--
作者：
M. SAEED uz ZAFAR;Raymond C. Mellinger;Gerald Fine;Marta Szabo;L. A. Frohman
肢端肥大症、垂体增大和血浆GH水平升高的患者同时患有支气管类癌。活动性肢端肥大症的体征和症状沿着GH水平升高，在垂体切除术和垂体柄切除术后持续了11年。切除支气管类癌后，血浆GH降至几乎检测不到的水平。提取物的冷冻类癌肿瘤没有显着的GH，但当添加到离体垂体细胞的雌激素引发的雄性大鼠在4天的原代培养表现出特定的GH释放活性在体外。这些发现强烈提示，患者的肢端肥大症是由支气管类癌分泌的生长激素释放因子持续刺激垂体生长激素细胞所致。
A patient with acromegaly, pituitary enlargement, and elevated plasma GH levels also had a bronchial carcinoid tumor. Signs and symptoms of active acromegaly along with elevated GH levels persisted for 11 yr after hypophysectomy and pituitary stalk section. Resection of the bronchial carcinoid reduced plasma GH to barely detectable levels. Extracts of the frozen carcinoid tumor were devoid of significant GH, but when added to isolated pituitary cells of estrogen-primed male rats in 4-day primary culture exhibited specific GH-releasing activity in vitro. These findings strongly suggest that the patient's acromegaly resulted from continual stimulation of pituitary somatotrophs by a GH-releasing factor secreted by the bronchial carcinoid.