Effects of antiepileptics on the hepatic storage of retinol.
Effects of antiepileptics on the hepatic storage of retinol.
复制标题
抗癫痫药对视黄醇肝脏储存的影响。
作者：
M. Botilsrud;K. Wathne;K. Norum;R. Blomhoff
检测不同抗癫痫药对大鼠肝脏视黄醇储存的影响。我们观察到，在服用其中几种药物后，肝脏中视黄醇的储存呈剂量和时间依赖性的减少。服用11周的苯巴比妥、扑草敏和卡马西平的剂量与人类使用的剂量相当，与对照组相比，肝脏中的视黄醇浓度降低了17%-33%。所有大鼠的血浆视黄醇水平均未受影响。31例癫痫患儿血浆视黄醇水平在0.7~2.4nmol/ml之间，正常。
The effect of various antiepileptics on the retinol storage in rat liver was tested. We observed a dose- and time-dependent reduction in the hepatic storage of retinol after the administration of several of these drugs. Administration for 11 weeks of phenobarbital, primidone and carbamazepine in doses comparable to those used in humans reduced the retinol concentration in the Liver by 17-33% compared to control rats. The plasma retinol levels remained unaffected in all the rats. Plasma retinol from 31 epileptic children had plasma levels between 0.7 and 2.4 nmol/ml, which is regarded as normal.