Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients
Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients
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DOI：
10.1016/s0920-9964(00)00028-1
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发表时间：
2000-11-30
影响因子：
4.5
通讯作者：
Magnotta, V
中科院分区：
文献类型：
--
作者：
Crespo-Facorro, B;Kim, JJ;Magnotta, V
岛叶皮层是一个边缘整合区，参与情感和认知功能。为了研究精神分裂症中可能的岛叶皮质异常，我们测量了首次发作的药物初治患者的岛叶灰质体积和皮质表面大小。应用磁共振成像技术对25例健康男性志愿者和25例男性精神分裂症患者的岛叶皮质进行了形态学观察。各组在年龄、性别、身高和父母的社会经济地位方面相匹配。临床维度评分与岛叶灰质体积和皮质表面积相关。患者的皮质表面积[患者=2020（206）;对照=2142（204）; F=5.83，df= 1，47; P=0.01]和灰质体积[患者=8.12（0.77）;对照组=8.57（0.94）; F=3.93，df =1.47;P=0.05]。岛叶灰质体积和皮质表面大小与精神病症状维度呈显著负相关。精神分裂症患者在疾病的早期阶段在岛叶皮层表现出形态学异常。这些异常与精神病症状的严重程度有关。需要进一步的调查，以评估的作用，在精神分裂症的病理生理。(C)2000 Elsevier Science B. V.保留所有权利。
The insular cortex is a limbic integration region that is engaged in emotional and cognitive functions. To investigate possible insular cortex abnormalities in schizophrenia, we measured insular gray matter volume and cortical surface size in drug-naive first-episode patients. Magnetic resonance images were used to explore the morphology of the insular cortex of 25 healthy male volunteers, and 25 male schizophrenic patients. Groups were matched for age, sex, height, and parental socio-economic status. Clinical dimension scores were correlated with insular gray matter volume and cortical surface area.Patients had a significant reduction in cortical surface area [patients=2020 (206); controls=2142 (204); F=5.83, df=1,47; P=0.01] and gray matter volume [patients=8.12 (0.77); controls=8.57 (0.94); F=3.93, df =1.47;P=0.05] in the left insular, cortex. Insular gray matter volume and cortical surface size correlated negatively and significantly with the psychotic symptom dimension. Schizophrenic patients show morphological abnormalities in the insular cortex at early stages of the illness. These abnormalities are related to the severity of psychotic symptoms. Further investigations are needed to evaluate the role of the insula in the pathophysiology of schizophrenia. (C) 2000 Elsevier Science B.V. All rights reserved.