Frequency-Dependent Modulation of Regional Synchrony in the Human Brain by Eyes Open and Eyes Closed Resting-States.
Frequency-Dependent Modulation of Regional Synchrony in the Human Brain by Eyes Open and Eyes Closed Resting-States.
复制标题
睁眼和闭眼静息状态对人脑区域同步的频率依赖性调节
DOI：
10.1371/journal.pone.0141507
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Gao JH
中科院分区：
文献类型：
--
作者：
Song X;Zhou S;Zhang Y;Liu Y;Zhu H;Gao JH
睁眼（EO）和闭眼（EC）状态对BOLD-fMRI信号动力学具有不同的影响，影响单个体素的BOLD振荡频率和几个相邻体素的区域均匀性（ReHo）。为了探索这两种静止状态如何通过不同的频带调制局部同步，我们将每个体素的时间序列分解为落入不同频带的几个分量。计算每个条带中的ReHo，并在EO和EC条件之间进行比较。还计算了两种状态之间的平均频率和每个体素的原始BOLD系列在不同脑区的整体ReHo之间的交叉体素相关性。与EC状态相比，EO在双侧丘脑、感觉运动网络和上级颞上回的0.01-0.25 Hz宽频带内降低ReHo，而在初级视皮层的0 ~ 0.01 Hz频带内显著升高ReHo，在高级视区的0.02-0.1 Hz高频带内显著升高ReHo。频率和整体ReHo之间的交叉体素相关性在所有脑区均为负，但因区域而异。在视觉网络和默认模式网络中，这些相关性与EO更强。我们的结果表明，不同频段的ReHo表现出不同的灵敏度调制的EO-EC状态。频率和整体ReHo地图之间的更好的空间一致性表明，大脑可能会采取更严格的频率依赖性配置与EO比与EC。
The eyes-open (EO) and eyes-closed (EC) states have differential effects on BOLD-fMRI signal dynamics, affecting both the BOLD oscillation frequency of a single voxel and the regional homogeneity (ReHo) of several neighboring voxels. To explore how the two resting-states modulate the local synchrony through different frequency bands, we decomposed the time series of each voxel into several components that fell into distinct frequency bands. The ReHo in each of the bands was calculated and compared between the EO and EC conditions. The cross-voxel correlations between the mean frequency and the overall ReHo of each voxel’s original BOLD series in different brain areas were also calculated and compared between the two states. Compared with the EC state, ReHo decreased with EO in a wide frequency band of 0.01–0.25 Hz in the bilateral thalamus, sensorimotor network, and superior temporal gyrus, while ReHo increased significantly in the band of 0–0.01 Hz in the primary visual cortex, and in a higher frequency band of 0.02–0.1 Hz in the higher order visual areas. The cross-voxel correlations between the frequency and overall ReHo were negative in all the brain areas but varied from region to region. These correlations were stronger with EO in the visual network and the default mode network. Our results suggested that different frequency bands of ReHo showed different sensitivity to the modulation of EO-EC states. The better spatial consistency between the frequency and overall ReHo maps indicated that the brain might adopt a stricter frequency-dependent configuration with EO than with EC.