Physical activity in the prevention of type 2 diabetes -: The Finnish Diabetes Prevention Study
Physical activity in the prevention of type 2 diabetes -: The Finnish Diabetes Prevention Study
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DOI：
10.2337/diabetes.54.1.158
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发表时间：
2005-01-01
期刊：
影响因子：
7.7
通讯作者：
Uusitupa, M
中科院分区：
文献类型：
--
作者：
Laaksonen, DE;Lindström, J;Uusitupa, M
临床试验表明，改变生活方式可以预防 2 型糖尿病，但休闲体育活动 (LTPA) 的重要性仍不清楚。我们对 487 名糖耐量受损的男性和女性完成了 12 个月的 LTPA 问卷调查，对 LTPA 在预防 2 型糖尿病中的作用进行了事后分析。受试者是芬兰糖尿病预防研究的参与者，这是一项生活方式改变（包括饮食、减肥和 LTPA）的随机对照试验。在 4.1 年的随访期间，新增糖尿病病例 107 例。增加中度至剧烈 LTPA 或剧烈、结构化 LTPA 最多的个体患糖尿病的可能性降低 63-65%。研究期间饮食和体重变化的调整在一定程度上减弱了这种关联（上三分之一与下三分之一：中度至剧烈 LTPA，相对风险 0.51，95% CI 0.260.97；剧烈、结构化 LTPA，0.63、0.35-1.13）。低强度和生活方式的 LTPA 和步行也能带来益处，这与总 LTPA 的变化（上三分之一与下三分之一：0.34、0.19-0.62）与糖尿病发病最密切相关的发现一致。因此，增加体力活动可能会显着降低高危人群 2 型糖尿病的发病率。
Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.260.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals.