Multiple papillomas of the breast: Is current management adequate?
Multiple papillomas of the breast: Is current management adequate?
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DOI：
10.1016/j.breast.2006.05.003
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发表时间：
2006-12-01
期刊：
影响因子：
3.9
通讯作者：
Saunders, Christobel M.
中科院分区：
文献类型：
--
作者：
Harift, Kaur;Willsher, Peter C.;Saunders, Christobel M.
多发性乳头状瘤（MP）在其临床和病理意义和管理方面存在争议。到目前为止，理想的管理仍然没有很好地建立起来。自1994年以来，皇家珀斯医院多学科乳腺服务前瞻性地积累了9000多名患者的临床和病理数据。查询数据库，并回顾性审查所有病理学报告。从1994年至2004年期间的数据库中共检索到23例诊断为MP的病例。在这23例病例中，13例（56.5%）通过芯活检诊断，9例（39.1%）通过切除活检诊断，1例（4.4%）通过乳房切除术标本诊断。平均年龄56.4岁（44-74岁），平均随访时间4.1年（1-10年）。在我们的系列研究中，发现MP与恶性肿瘤密切相关，也与一系列增生性乳腺疾病相关。应该为这种有争议的情况制定当代指南。我们建议所有MP患者，尤其是合并有脑膜炎的患者，应广泛切除病灶，边缘清晰至少10 mm，并通过每年影像学检查密切监测这些患者。(c)2006爱思唯尔有限公司保留所有权利。
Multiple papillomas (MP) are subject to debate in terms of their clinical and pathological significance and management. To date the ideal management is still not well established. The Royal Perth Hospital Multidisciplinary Breast Service has prospectively accrued clinical and pathological data on over 9000 patients since 1994. The database was interrogated and all pathology reports retrospectively reviewed. A total of 23 cases with the diagnosis of MP were retrieved from the database between 1994 and 2004. Of these 23 cases, 13 (56.5%) were diagnosed by core biopsy, nine (39.1%) on excision biopsy, and one (4.4%) on a mastectomy specimen. The average age of patients was 56.4 years (range 44-74 years).The average duration of follow up is 4.1 years (range 1-10 years). In our series a close association with malignancy was noted for MP, which was also associated with a spectrum of proliferative breast disease. Contemporary guidelines should be developed for this controversial condition. We recommend that all patients with MP, especially when associated with atypia, undergo wide excision of the lesion with clear margins of at least 10 mm and that these patients be monitored closely with annual imaging. (c) 2006 Elsevier Ltd. All rights reserved.