Basic fibroblast growth factor enhances axonal sprouting after cortical injury in rats.
Basic fibroblast growth factor enhances axonal sprouting after cortical injury in rats.
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DOI：
10.1097/00001756-199904260-00008
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发表时间：
1999-04
期刊：
影响因子：
1.7
通讯作者：
J. J. Ramirez-J.;S. Finklestein;J. Keller;W. Abrams;M. George;T. Parakh
中科院分区：
文献类型：
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作者：
J. J. Ramirez-J.;S. Finklestein;J. Keller;W. Abrams;M. George;T. Parakh
在这个世纪的大部分时间里，负责启动和引导轴突生长的营养因子被证明是难以捉摸的。内嗅皮层损伤，失神经支配的大鼠海马结构，诱导轴突发芽的几个幸存的海马传入，并导致生长因子，其中之一是碱性成纤维细胞生长因子（bFGF）的显着升高。bFGF可以调节病变诱导的海马发芽的可能性进行了检查，使i.v. bFGF输注到大鼠单侧内嗅病变。碱性成纤维细胞生长因子处理通过胆碱能隔齿途径显着增加发芽。因此，中枢神经系统损伤后碱性成纤维细胞生长因子的增加可能表明其在胆碱能通路损伤相关轴突重塑的调节中的作用。
The trophic factors responsible for initiating and guiding the outgrowth of axons have proven to be elusive throughout most of this century. Entorhinal cortex injury, which denervates the hippocampal formation of rats, induces axonal sprouting by several surviving hippocampal afferents and results in a significant elevation of growth factors, one of which is basic fibroblast growth factor (bFGF). The possibility that bFGF may regulate lesion-induced hippocampal sprouting was examined by making i.v. bFGF infusions into rats with unilateral entorhinal lesions. Basic FGF treatment significantly increased sprouting by the cholinergic septodentate pathway. Thus, the increase in bFGF following central nervous system injury may signal its role in the regulation of injury-related axonal remodeling of a cholinergic pathway.