Assessment of mitral regurgitation severity by Doppler color flow mapping of the vena contracta in dogs.
Assessment of mitral regurgitation severity by Doppler color flow mapping of the vena contracta in dogs.
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DOI：
10.1111/jvim.12380
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发表时间：
2014-07
影响因子：
2.6
通讯作者：
Brambilla PG
中科院分区：
文献类型：
--
作者：
Di Marcello M;Terzo E;Locatelli C;Palermo V;Sala E;Dall'Aglio E;Bussadori CM;Spalla I;Brambilla PG
已经提出了定量和半定量的方法来评估MR的严重程度，尽管这些方法都有局限性。收缩静脉宽度(VCW)的测量已应用于临床。测量不同严重程度MR犬的VCW。将279只犬按5级MR严重程度进行分类。这是一项回溯性研究。用PISA法计算EROA和返流体积，并以BSA为指标。计算所有MR严重程度的VCW和VCW指数的描述性统计。计算Spearman‘s等级相关系数(ρS)，比较不同方法(VCW和VCW指数与RV PISA、RV PISA指数、EROA、EROA指数)以及VCW和VCW指数与MR严重程度的关系。所有Spearman‘s等级相关系数均达到显著水平(P<0.01)。在先前被归类为轻度至中度和中度至重度组中，VCW的中位数分别为2.9 mm(IQR 3.4-2.5)和4.6 mm(IQR 5.4-4.1)。在轻中度MR和中重度MR中，VCW指数的中位值分别为4.4 mm/m2(IQR=4.55-4.2)和10.8 mm/m2(IQR=10.8-9.4)。这不是针对任何先前验证的侵入性金标准的验证性研究，VCW方法已被证明易于使用，它可能是一种额外的量化疾病严重程度的工具，支持而不是取代日常临床实践和研究中来自其他技术的数据。
Quantitative and semiquantitative methods have been proposed for the assessment of MR severity, and though all are associated with limitations. Measurement of vena contracta width (VCW) has been used in clinical practice. To measure the VCW in dogs with different levels of MR severity. Two hundred and seventy‐nine dogs were classified according to 5 levels of MR severity. This was a retrospective study. EROA and regurgitant volume calculated by the PISA method, were measured and indexed to BSA. Descriptive statistics were calculated for VCW and VCW index for all categories of MR severity. Spearman's rank correlation coefficients (ρs) were calculated to compare the results of the different methods (VCW and VCW index vs RV PISA, RV PISA index, EROA, EROA index), and between VCW and VCW index versus MR severity. All Spearman's rank correlation coefficients were significant (P < .001). The median values of VCW resulted of 2.9 mm (IQR 3.4–2.5) and of 4.6 mm (IQR 5.4–4.1) in the groups previously classified as mild‐to‐moderate and moderate‐to‐severe, respectively. The median values of VCW index resulted of 4.4 mm/m2 (IQR = 5.5–4.2) in mild‐to‐moderate MR and of 10.8 mm/m2 (IQR = 12.8–9.4) in moderate‐to‐severe MR. This is not a validation study against any previously validated invasive gold standard, the VCW method has proved easy to employ and it might be an additional tool in quantifying disease severity that supports, rather than replace, data coming from other techniques in daily clinical practice and research.