DACH1 as a multifaceted and potentially druggable susceptibility factor for kidney disease.
DACH1 as a multifaceted and potentially druggable susceptibility factor for kidney disease.
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DOI：
10.1172/jci149043
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发表时间：
2021-05
期刊：
影响因子：
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通讯作者：
Sandra Merscher;C. Faul
中科院分区：
文献类型：
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作者：
Sandra Merscher;C. Faul
肾脏疾病影响了美国15%以上的成年人，但与其他常见疾病相比，肾脏领域的药物开发一直落后。增加对损伤的易感性并有助于肾脏疾病的发病机制和进展的修饰因子包括遗传和环境因素以及表观遗传机制。在这一期的JCI中，Cao等人和Doke等人独立地报告了一种称为腊肠犬同源物1（DACH 1）的易感因子的鉴定。这两个研究小组使用不同的筛选方法，研究不同类型的人类肾脏疾病，并使用不同的实验模型，确定了DACH1表达减少与肾脏疾病的关联，这使得两个人都被同一种蛋白质绊倒的事实非常引人注目。结合起来，这些研究强调DACH1是肾脏的关键保障，通过调节几种分子途径赋予各种细胞类型适当的功能。
Kidney diseases affect more than 15% of adults in the US, yet drug development in the kidney field, when compared with that for other common diseases, has been lagging behind. Modifiers that increase the susceptibility to injury and contribute to the pathogenesis and progression of kidney disease include genetic and environmental factors and epigenetic mechanisms. In this issue of the JCI, Cao et al. and Doke et al. independently report the identification of a susceptibility factor called Dachshund homolog 1 (DACH1). Both groups identify an association of reduced DACH1 expression with kidney disease, using different screening approaches, studying different types of human kidney diseases, and using different experimental models, making the fact that both stumbled over the same protein very compelling. Combined, these studies highlight DACH1 as a key safeguard in the kidney, granting various cell types proper function by modulating several molecular pathways.