PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSE
PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSE
复制标题
DOI：
10.1111/j.1476-5381.1957.tb01354.x
复制
发表时间：
1957-01-01
期刊：
影响因子：
--
通讯作者：
MCCORMICK, WG
中科院分区：
文献类型：
--
作者：
HALEY, TJ;MCCORMICK, WG
本文介绍了一种研究非麻醉小鼠脑内注射药物所产生的中枢效应的方法。观察到的效果与在猫、狗和人类身上进行类似注射后获得的效果非常一致。脑内注射不同结构的药物后，会产生一定的全身效应：尾巴位置改变、昏迷、兴奋性亢进和呼吸急促。乙酰胆碱和乙酰胆碱均引起癫痫发作和抑郁，但后者也引起流泪和流口水。阿托品引起勃起，对声音和触摸、阵挛抽搐和抓挠的敏感度增加，而六甲溴铵引起帕金森样肌肉震颤和外周血管扩张。在肾上腺素作用后，观察到过度兴奋、眼球突出、昏迷和肺水肿死亡，但(+)-甲基苯丙胺只产生飞行员勃起和对声音和触摸的夸大活动。麦角胺导致对声音和触摸、排尿和昏迷的敏感度降低，而麦角碱引起阵挛抽搐、勃起、排便和昏迷。
A method has been described for the study of the central effects produced by the intracerebral injection of drugs in the unanaesthetized mouse. The effects observed were in good agreement with those obtained after similar injections in cats, dogs and human beings. After intracerebral injection, drugs of diverse structure produced certain generalized effects: changes in positioning of the tail, stupor, hyperexcitability and tachypnoea. Both acetylcholine and methacholine produced an akinetic seizure and depression, but the latter compound also caused lacrimation and salivation. Atropine produced piloerection, increased sensitivity to sound and touch, clonic convulsions and scratching, whereas hexamethonium caused Parkinsonian‐like muscle tremors and peripheral vasodilatation. After adrenaline, hyperexcitability, exophthalmos, stupor and death from pulmonary oedema were observed, but (+)‐methylamphetamine produced only piloerection and exaggerated activity in response to sound and touch. Ergotamine caused a decreased sensitivity to sound and touch, micturition, and stupor, while ergometrine caused clonic convulsions, piloerection, defaecation and stupor.