Nickel-catalyzed asymmetric Negishi cross-couplings of secondary allylic chlorides with alkylzincs
Nickel-catalyzed asymmetric Negishi cross-couplings of secondary allylic chlorides with alkylzincs
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DOI：
10.1021/ja800103z
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发表时间：
2008-03-05
影响因子：
15
通讯作者：
Fu, Gregory C.
中科院分区：
文献类型：
--
作者：
Son, Sunghee;Fu, Gregory C.
为了补充以前在烯丙化化学方面的进展，开发了一种有效的镍/PYBOX催化剂，用于外消旋仲烯丙基氯化物与易于获得的有机卤化锌的区域选择性不对称Negishi交叉偶联。该方法已应用于氟尿嘧啶A(1)的正式全合成的两个关键步骤。
Complementing previous advances in allylation chemistry, an effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A(1).