High maternal osteocalcin levels during pregnancy is associated with low birth weight infants: A nested case-control study in China.
High maternal osteocalcin levels during pregnancy is associated with low birth weight infants: A nested case-control study in China.
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怀孕期间母体骨钙素水平高与婴儿出生体重低有关：中国的一项巢式病例对照研究。
DOI：
10.1016/j.bone.2018.07.009
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发表时间：
2018
期刊：
影响因子：
4.1
通讯作者：
Xu Jianfeng
中科院分区：
文献类型：
--
作者：
Wei Luyun;Cao Dehao;Zhu Xiujuan;Long Yu;Liu Chaoqun;Huang Shengzhu;Tian Jiarong;Hou Qingzhi;Huang Yaling;Ye Juan;Luo Bangzhu;Luo Ying;Liang Chunmei;Li Mujun;Yang Xiaobo;Mo Zengnan;Xu Jianfeng
背景低出生体重儿(LBW)孕期能量代谢紊乱，是晚年慢性病的高危人群。骨钙素(OC)是一种调节能量代谢的激素。目的探讨孕妇血清OC水平与低出生体重儿的关系。方法采用嵌套式病例对照研究方法，共纳入230例低出生体重儿和382例对照孕妇(婴儿性别、采血时胎龄、妇幼保健院所在地和产妇年龄按1：(1~2)比例配对)。每名孕妇在妊娠5-35 周时采集一份血清样本。将孕妇分为3组(妊娠1、2、3周组)。分别有60名、142名和28名孕妇在妊娠早期、中期和晚期分娩LBW。同样，在第一、第二和第三个三个月分别有101个和233个和48个对照。母体血清OC和25(OH)D水平分为低水平和高水平，低水平作为分析的参考。采用二元Logistic回归模型，根据母体血清OC和2 5(OH)D水平计算低出生体重的OR值。结果与早孕期血清OC水平低的孕妇相比，血清OC水平高的孕妇发生低体重的可能性是低体重的2倍(OR = 2.0 4，95%CI：1.0 5~3.96)。在调整混杂因素后，仍存在显著的正相关关系(调整后的ORS值 = 为2.2 9，95%CI：1.11~4.72)。在妊娠中期，血清OC水平高的孕妇分娩低体重儿的风险是血清OC水平低的孕妇的1.6倍(OR = 为1.5 5，95%CI：1.0 1~2.37)。调整混杂因素后，OR值增加(ORs = 为1.5 9，95%CI：1.0 3~2.45)。未发现妊娠晚期母体血清OC水平与LBW显著相关。此外，孕期母体25(OH)D水平与LBW无相关性。结论妊娠早、中期母体血清OC水平升高可能与LBW的发病风险有关。
BackgroundLow birth weight infants (LBW) are at risk of chronic diseases in later life due to the disorder of energy metabolism during pregnancy. Osteocalcin (OC) has been identified as a hormone that regulate energy metabolism. However, few studies have researched on the associations between maternal serum OC levels and low birth weight infants.ObjectionsTo examine the associations between maternal serum OC concentrations and LBW.MethodsThis was a nested case-control study involving a total of 230 pregnant women delivering LBW and 382 control pregnant women (matched for infant gender, gestational age at blood draw, region of Maternity and Child Healthcare Hospital and maternal age in 1: (1–2) ratio). One serum sample was collected from each pregnant woman at 5–35 weeks' gestation. Pregnant women were divided into 3 groups (1st, 2nd and 3rd trimester group). There were 60 and 142 and 28 pregnant women delivering LBW in the first, second and third trimester, respectively. Similarly, there were 101 and 233 and 48 controls in the first, second and third trimester, respectively. Maternal serum OC and 25(OH)D concentrations were categorized into low and high levels, the low level used as reference in analyses. Binary logistic regression model was used to compute odd radio (ORs) for LBW according to levels of maternal serum OC and 25(OH)D.ResultsCompared with the subjects in low level in first trimester, LBW was two times as likely to occur among pregnancy women with high serum OC concentrations (OR = 2.04, 95%CI:1.05–3.96). After adjusted for confounding factors, a significant positive relationship still existed (adjusted ORs = 2.29, 95%CI: 1.11–4.72). In second trimester, women in high level of serum OC had nearly 1.6 times the risk of delivering LBW infants as those in the low level (OR = 1.55, 95%CI: 1.01–2.37). After adjusted for confounding factors, the ORs increased (ORs = 1.59, 95%CI:1.03–2.45). No significant associations were found between maternal serum OC levels and LBW in third trimester. In addition, there were no associations between maternal 25(OH)D concentrations and LBW during pregnancy.ConclusionHigh maternal serum OC levels in the first or the second trimester during pregnancy may be associated with the risk of LBW.