Efficacy of ultrafiltration in removing inflammatory mediators during pediatric cardiac operations.
Efficacy of ultrafiltration in removing inflammatory mediators during pediatric cardiac operations.
复制标题
超滤在儿科心脏手术期间去除炎症介质的功效。
DOI：
10.1016/0003-4975(95)00974-4
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
S. Chu
中科院分区：
文献类型：
--
作者：
M. Wang;Ing;Chao;Chao;P. Lin;Chung;Chi;S. Chu
[背景]在小儿心脏手术中采用常规超滤和改良超滤，以减少容量超负荷和减少全身积水。本研究的目的是比较这些技术在体外循环期间清除炎症介质的效果。方法将50例接受心脏手术的儿童患者随机分为改良超滤组和常规超滤组。结果除改良超滤组外，两组患者超滤后血浆中除肿瘤坏死因子-α外，其余指标均较超滤前升高。改良组的超滤量、超滤液中肿瘤坏死因子-α和白介素6的总清除量明显高于对照组。超滤液中的介质浓度和超滤液与血浆浓度的比值在两组之间没有差异。超滤对肿瘤坏死因子-α的清除效果优于其他两种介质。结论改良超滤对体外循环中产生的炎性介质的清除效果与传统超滤无明显差异。
BACKGROUNDConventional and modified ultrafiltration was used in pediatric cardiac operations to reduce volume overload and total body water. The purpose of this study was to compare the efficacy of these techniques in removing inflammatory mediators during cardiopulmonary bypass.METHODSFifty pediatric patients undergoing cardiac operations were randomized into a modified or conventional ultrafiltration group. Blood samples were obtained before and after ultrafiltration to assess the plasma concentrations of leukocyte elastase, tumor necrosis factor-α, interleukin-6, and interleukin-8.RESULTSExcept for plasma concentrations of tumor necrosis factor-α in the modified ultrafiltration group, the plasma concentrations of all the mediators measured increased after ultrafiltration in both groups of patients. The volume of ultrafiltrate and the total amounts of tumor necrosis factor-α and interleukin-6 removed by ultrafiltration were significantly greater in the modified group. The concentrations of mediators in the ultrafiltrate and the ratio of ultrafiltrate to plasma concentrations of the mediators did not differ between the groups. Ultrafiltration was more efficient in removing tumor necrosis factor-α than the other mediators.CONCLUSIONSThe efficacy in removing the inflammatory mediators generated during cardiopulmonary bypass did not differ between modified and conventional ultrafiltration.