Schizophrenia: the systematic construction of genetic models.
Schizophrenia: the systematic construction of genetic models.
复制标题
精神分裂症：遗传模型的系统构建。
DOI：
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发表时间：
1980
影响因子：
9.8
通讯作者：
J. Stewart
中科院分区：
文献类型：
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作者：
J. Stewart
本文描述了用一个、两个和四个位点系统构建精神分裂症遗传模型的方法。所有模型都被约束以拟合以下三个参数：（1）一般人群中精神分裂症的频率= 0.9%;（2）精神分裂症患者同胞中精神分裂症的频率= 8%;（3）精神分裂症患者同胞中“精神分裂症谱”的频率= 15%。此外，第四个参数，易患精神分裂症的等位基因的频率，是自由可变的。校正的问题，确定偏差，比较和测试这些遗传模型，进行了讨论。
Methods are described for the systematic construction of genetic models of schizophrenia with one, two, and four loci. All models are constrained to fit the following three parameters: (1) frequency of schizophrenia in the general population = 0.9%; (2) frequency of schizophrenia in the sibs of schizophrenics = 8%; and (3) frequency of "schizophrenic spectrum" in the sibs of schizophrenics = 15%. In addition, a fourth parameter, the frequency of the allele predisposing to schizophrenia, is freely variable. The problems of correcting for ascertainment bias, and of comparing and testing these genetic models, are discussed.