ANGIOTENSINOGEN MESSENGER-RNA AND PRESSOR REACTIONS TO ANGIOTENSIN IN BRAIN-STEM AREAS OF SPONTANEOUSLY HYPERTENSIVE RATS
ANGIOTENSINOGEN MESSENGER-RNA AND PRESSOR REACTIONS TO ANGIOTENSIN IN BRAIN-STEM AREAS OF SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.3109/10641969309041638
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发表时间：
1993-01-01
影响因子：
12.3
通讯作者：
GANTEN, D
中科院分区：
文献类型：
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作者：
CHAI, CY;HELLMANN, W;GANTEN, D
血管紧张素（ANG II）在组织水平，特别是在大脑中的作用，仍然不完全确定。 我们测量血管紧张素原（A度）mRNA在脑干，感觉和交感神经节，血管的Wistar-Kyoto（WKY）和易卒中的自发性高血压大鼠（SHR-SP）的定量，液体杂交。 我们将ANG II和谷氨酸微量注射到这些大鼠的脑干中，以深入了解我们发现的功能意义。 A度mRNA被发现在背外侧，背内侧，和腹外侧脑桥，以及在背外侧，背内侧，和腹外侧髓质的两个菌株。 A-度mRNA的8-10 pg/mug总mRNA高（p <0.05）。
The role of angiotensin (ANG II) at the tissue level, particularly in the brain, remains imperfectly defined. We measured angiotensinogen (A-degrees) mRNA in the brain stems, sensory and sympathetic ganglia, and blood vessels of Wistar-Kyoto (WKY) and stroke-prone spontaneously hypertensive rats (SHR-SP) by quantitative, liquid hybridization. We micro-injected ANG II and glutamate into the brain stems of these rats to gain insight into the functional significance of our findings. A-degrees mRNA was found in the dorsolateral, dorsomedial, and ventrolateral pons, as well as in the dorsolateral, dorsomedial, and ventrolateral medulla of both strains. A-degrees mRNA was 8-10 pg/mug total mRNA higher (p