Fusion of cells by flipped SNAREs
Fusion of cells by flipped SNAREs
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DOI：
10.1126/science.1084909
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发表时间：
2003-06-13
期刊：
影响因子：
56.9
通讯作者：
Rothman, JE
中科院分区：
文献类型：
--
作者：
Hu, C;Ahmed, M;Rothman, JE
SNARE（可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体）假说表明，称为囊泡（v-）SNARE和靶膜（t-）SNARE的蛋白质对特异性相互作用，以控制和介导细胞内膜融合事件。在此，发现在细胞表面上表达v-和t-SNARE的相互作用结构域的细胞自发融合，表明SNARE足以融合生物膜。
The SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) hypothesis suggests that pairs of proteins known as vesicle (v-) SNAREs and target membrane (t-) SNAREs interact specifically to control and mediate intracellular membrane fusion events. Here, cells expressing the interacting domains of v- and t- SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes.