Nonsteroidal anti-inflammatory drugs and prostate cancer risk in the VITamins And Lifestyle (VITAL) cohort.
Nonsteroidal anti-inflammatory drugs and prostate cancer risk in the VITamins And Lifestyle (VITAL) cohort.
复制标题
维生素和生活方式（生命）队列中的非甾体类抗炎药和前列腺癌的风险。
DOI：
10.1158/1055-9965.epi-10-0942
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
White E
中科院分区：
文献类型：
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作者：
Brasky TM;Velicer CM;Kristal AR;Peters U;Potter JD;White E
慢性炎症在前列腺癌发生中可能是重要的。一些流行病学研究报告了非甾体抗炎药（NSAID）和前列腺癌风险之间的负相关性，尽管许多研究仅限于短期使用的评估。参与者是VITAMIN和生活方式队列的男性成员，包括34，132名年龄在50-76岁之间的男性，居住在华盛顿州西部。使用考克斯比例风险模型估计10年平均使用个体NSAID与总前列腺癌（n= 1，550）和前列腺癌分级的校正风险比（HR）和95%置信区间（95% CI）。低剂量阿司匹林、常规强度阿司匹林、布洛芬和任何非阿司匹林NSAID（布洛芬、萘普生和考克斯-2抑制剂）与前列腺癌风险无关。有证据表明，常规剂量阿司匹林与高级别癌症风险呈负相关（HR 0.73，95% CI：0.53-1.02）。在VITAL队列中，NSAID的使用与前列腺癌风险无关。我们的研究结果不支持使用非甾体抗炎药进行前列腺癌的化学预防。
Chronic inflammation may be important in prostate carcinogenesis. Several epidemiologic studies have reported inverse associations between non-steroidal anti-inflammatory drugs (NSAIDs) and prostate cancer risk, although many studies are limited by assessment of short-term use only. Participants were male members of the VITamins And Lifestyle cohort, comprised of 34,132 men, age 50-76 years, living in western Washington State. Cox proportional hazards models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) of 10-year average use of individual NSAIDs with total prostate cancer (n=1,550) and prostate cancer by grade. Low-dose aspirin, regular-strength aspirin, ibuprofen, and any non-aspirin NSAID (ibuprofen, naproxen, and COX-2 inhibitors) were not associated with prostate cancer risk. There was a suggestion that regular-strength aspirin was inversely associated with risk of high-grade cancer (HR 0.73, 95% CI: 0.53-1.02). NSAID use was not associated with prostate cancer risk in the VITAL cohort. Our findings do not support the use of NSAIDs for chemoprevention of prostate cancer.