A Bitter Sweet Symphony: Immune Responses to Altered O-glycan Epitopes in Cancer.
A Bitter Sweet Symphony: Immune Responses to Altered O-glycan Epitopes in Cancer.
复制标题
DOI：
10.3390/biom6020026
复制
发表时间：
2016-05-03
期刊：
影响因子：
5.5
通讯作者：
Van Vliet SJ
中科院分区：
文献类型：
--
作者：
Cornelissen LA;Van Vliet SJ
肿瘤细胞表面异常聚糖的出现是癌症的新标志之一。糖基化是蛋白质和脂质的重要翻译后修饰，并且受到肿瘤发生的强烈影响。肿瘤相关聚糖的组成和肿瘤类型特异性表达模式已得到广泛表征。然而，肿瘤相关聚糖是否以及如何促进所观察到的肿瘤免疫调节作用尚未得到广泛研究。在这里，我们提供了一个详细的概述，目前的知识，肿瘤相关的O-聚糖如何影响抗肿瘤免疫反应，从而集中在截断的O-聚糖上皮肿瘤和粘蛋白。这些肿瘤相关的0-聚糖和粘蛋白结合免疫细胞上的多种凝集素受体，以促进随后诱导致耐受性免疫应答。因此，我们假设肿瘤相关聚糖不仅支持肿瘤生长，而且还积极促进免疫逃避。
The appearance of aberrant glycans on the tumor cell surface is one of the emerging hallmarks of cancer. Glycosylation is an important post-translation modification of proteins and lipids and is strongly affected by oncogenesis. Tumor-associated glycans have been extensively characterized regarding their composition and tumor-type specific expression patterns. Nevertheless whether and how tumor-associated glycans contribute to the observed immunomodulatory actions by tumors has not been extensively studied. Here, we provide a detailed overview of the current knowledge on how tumor-associated O-glycans affect the anti-tumor immune response, thereby focusing on truncated O-glycans present on epithelial tumors and mucins. These tumor-associated O-glycans and mucins bind a variety of lectin receptors on immune cells to facilitate the subsequently induction of tolerogenic immune responses. We, therefore, postulate that tumor-associated glycans not only support tumor growth, but also actively contribute to immune evasion.