New Insights Into the Pathogenesis of Renal Calculi
New Insights Into the Pathogenesis of Renal Calculi
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DOI：
10.1016/j.ucl.2012.09.006
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发表时间：
2013-02-01
影响因子：
2.4
通讯作者：
Stoller, Marshall L.
中科院分区：
文献类型：
--
作者：
Bagga, Herman Singh;Chi, Thomas;Stoller, Marshall L.
各种形式的尿路结石疾病的病理生理学仍然是一个复杂的话题。流行病学研究以及对尿液和血清化学的研究创造了丰富的数据，有助于推动病理生理学理论的形成。本文讨论了尿路结石疾病与高血压、心血管疾病、动脉粥样硬化、肥胖、血脂异常、糖尿病和其他疾病状态的关系。关于膳食钙和兰德尔斑块形成的影响的研究结果也进行了探讨，并讨论了其意义。最后，探讨了进一步的研究途径，包括遗传分析和尿路结石疾病动物模型的使用。
The pathophysiology of the various forms of urinary stone disease remains a complex topic. Epidemiologic research and the study of urine and serum chemistries have created an abundance of data to help drive the formulation of pathophysiologic theories. This article addresses the associations of urinary stone disease with hypertension, cardiovascular disease, atherosclerosis, obesity, dyslipidemia, diabetes, and other disease states. Findings regarding the impact of dietary calcium and the formation of Randall's plaques are also explored and their implications discussed. Finally, further avenues of research are explored, including genetic analyses and the use of animal models of urinary stone disease.