INTERRELATIONSHIPS BETWEEN URINARY SODIUM, CALCIUM, HYDROXYPROLINE AND SERUM PTH IN HEALTHY-SUBJECTS
INTERRELATIONSHIPS BETWEEN URINARY SODIUM, CALCIUM, HYDROXYPROLINE AND SERUM PTH IN HEALTHY-SUBJECTS
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DOI：
10.1530/acta.0.1270242
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发表时间：
1992-09-01
期刊：
影响因子：
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通讯作者：
SWAMINATHAN, R
中科院分区：
文献类型：
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作者：
CHAN, ELP;HO, CS;SWAMINATHAN, R
研究了钠摄入量对钙、羟脯氨酸（OHP）和血清甲状旁腺激素（PTH）排泄的影响。当七名健康男性的钠摄入量增加 200 mmol/天时，钙的排泄量增加 1. 70 mmol/天，OHP 的排泄量增加 2. 7%。然而血清PTH并没有显着升高。在一项针对 334 名健康女性受试者的横断面研究中，空腹尿钠/肌酐 (Na/Cr) 和钙/肌酐 (Ca/Cr) 比率 (r = 0. 5 73) 以及 Na/Cr 和尿 OHP/Cr 比率 (r = 0.246) 之间存在很强的正相关性。血清 PTH 与 Na/Cr 比值呈负相关 (r = -0.161)。我们的结论是，饮食中钠的增加会导致钙尿和羟脯氨酸排泄增加。结果不支持这是由 PTH 介导的假设。
The effect of sodium intake on the excretion of calcium, hydroxyproline (OHP) and serum parathyroid hormone (PTH) was examined. When seven healthy males increased their sodium intake by 200 mmol/day, excretion of calcium increased by 1. 70 mmol/day and that of OHP by 2 7%. Serum PTH, however, did not increase significantly. In a cross-sectional study of 334 healthy female subjects there were strong positive correlations between fasting urinary sodium/creatinine (Na/Cr) and calcium/creatinine (Ca/Cr) ratios (r = 0. 5 73) and between Na/Cr and urinary OHP/Cr ratios (r = 0.246). Serum PTH was negatively correlated with Na/Cr ratio (r = -0.161). We conclude that an increase in dietary sodium causes calciuria and an increase in hydroxyproline excretion. The results do not support the hypothesis that this is mediated by PTH.