A specific test of hippocampal deficit in schizophrenia
A specific test of hippocampal deficit in schizophrenia
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DOI：
10.1037/0735-7044.119.4.863
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发表时间：
2005-08-01
影响因子：
1.9
通讯作者：
Cañive, JM
中科院分区：
文献类型：
--
作者：
Hanlon, FM;Weisend, MP;Cañive, JM
尽管有大量研究发现海马异常，但精神分裂症患者的海马神经活动尚未在特定的海马依赖性任务上进行系统评估。横向模式任务（TP）对海马体的关系记忆能力很敏感。 10 名精神分裂症患者和 10 名对照者执行了不依赖海马的 TP 和控制任务。正如预测的那样，患者在 TP 中表现出行为障碍，但在控制任务中没有表现出行为障碍。脑磁图显示对照组在 TP 表演期间激活右侧海马体。患者在 TP 期间表现出更多的双侧或左侧海马激活，并且更大的左侧化与更好的 TP 表现相关。患者异常的海马偏侧化可能在海马依赖性行为缺陷中发挥作用。
Despite numerous studies in which hippocampal abnormalities were found, schizophrenia patients' hippocampal neural activity has not been systematically evaluated on a specific hippocampal-dependent task. The transverse-patterning task (TP) is sensitive to the relational mnemonic capabilities of the hippocampus. Ten schizophrenia patients and 10 controls performed TP and control tasks that are not hippocampal dependent. As predicted, patients displayed a behavioral impairment in TP and not in control tasks. Magnetoencephalography showed controls activating right hippocampus during TP performance. Patients showed more bilateral or left hippocampal activation during TP, and greater left lateralization was associated with better performance on TP. Patients' abnormal hippocampal lateralization may play a role in the hippocampal-dependent behavioral deficit.