The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data
The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data
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DOI：
10.1093/nar/gkh028
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Thornton, JM
中科院分区：
文献类型：
--
作者：
Porter, CT;Bartlett, GJ;Thornton, JM
催化位点图谱（CSA）为蛋白质数据库中的酶提供催化残基注释。可在http://www.ebi.ac.uk/ thornton-srv/databases/CSA上查阅。该数据库由两种类型的注释网站：一个原始的手工注释集，包含从主要文献中提取的信息，使用定义的标准分配催化残基，和一个额外的同源集，包含PSI-BLAST推断的注释和序列比对的原始集之一。CSA可通过Swiss-Prot标识符和EC编号以及PDB代码进行查询。CSA版本1.0包含177个原始手工注释条目和2608个同源条目，覆盖了PDB中所有EC编号的30%。CSA将每月更新一次，以包括在新PDB中发现的同源位点，以及在注释完成后的新手工注释酶。
The Catalytic Site Atlas (CSA) provides catalytic residue annotation for enzymes in the Protein Data Bank. It is available online at http://www.ebi.ac.uk/ thornton-srv/databases/CSA. The database consists of two types of annotated site: an original hand-annotated set containing information extracted from the primary literature, using defined criteria to assign catalytic residues, and an additional homologous set, containing annotations inferred by PSI-BLAST and sequence alignment to one of the original set. The CSA can be queried via Swiss-Prot identifier and EC number, as well as by PDB code. CSA Version 1.0 contains 177 original hand-annotated entries and 2608 homologous entries, and covers similar to30% of all EC numbers found in PDB. The CSA will be updated on a monthly basis to include homologous sites found in new PDBs, and new hand-annotated enzymes as and when their annotatation is completed.