Effect of Age and Sex on Human Drug Metabolism
Effect of Age and Sex on Human Drug Metabolism
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年龄和性别对人类药物代谢的影响
作者：
K. O'malley;J. Crooks;E. Duke;I. Stevenson
对老年医院住院患者的药物代谢能力进行了测量。研究发现，患者使用安替比林和保泰松的平均血浆半衰期值分别比年轻对照者高 45% 和 29%。当仅考虑女性时，老年组中安替比林的半衰期延长了 78%。在许多老年人中，发现这两种药物的代谢速度极其缓慢。这种药物代谢能力的下降可能导致老年人药物不良反应的高发生率。在对照组中，安替比林代谢率存在显着的性别差异，男性的平均半衰期长 30%。从这些结果可以清楚地看出，在人体药物代谢研究中必须考虑受试者的年龄和性别。
The capacity of inpatients in a geriatric hospital to metabolize drugs was measured. The mean plasma half-life values with antipyrine and with phenylbutazone were found to be 45% and 29% greater respectively in patients than in young controls. When women alone were considered the half-life of antipyrine was 78% longer in the elderly group. In a number of elderly individuals the rate of metabolism of these two drugs was found to be extremely slow. This decreased ability to metabolize drugs may contribute to the known high incidence of adverse drug reactions in the elderly. Within the control group a significant sex difference in the rate of antipyrine metabolism was found, the mean half-life being 30% longer in the males. It is clear from these results that the age and sex of subjects must be taken into account in studies of human drug metabolism.