Corneal confocal microscopy: A novel means to detect nerve fibre damage in idiopathic small fibre neuropathy
Corneal confocal microscopy: A novel means to detect nerve fibre damage in idiopathic small fibre neuropathy
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DOI：
10.1016/j.expneurol.2009.08.033
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发表时间：
2010-05-01
影响因子：
5.3
通讯作者：
Malik, Rayaz A.
中科院分区：
文献类型：
--
作者：
Tavakoli, Mitra;Marshall, Andrew;Malik, Rayaz A.
特发性小纤维神经病（ISFN）患者有明显的表皮内神经纤维损失和糖耐量受损（IGT）的患病率增加。有研究表明，IGT血糖异常和其他代谢危险因素可能导致这些患者的小神经纤维损伤。25名ISFN患者和12名年龄匹配的对照组接受了详细的神经病变症状、神经功能缺损(神经病变缺损评分（NDS）；神经传导研究（NCS）；定量感觉测试（QST）和角膜共聚焦显微镜（CCM）来量化小神经纤维病理。8例（32%）患者有IGT。所有ISFN患者均有明显的神经性症状，除温阈外，NDS、NCS和QST均正常。角膜敏感性降低，CCM显示角膜神经纤维密度（NFD）显著降低(P
Patients with idiopathic small fibre neuropathy (ISFN) have been shown to have significant intraepidermal nerve fibre loss and an increased prevalence of impaired glucose tolerance (IGT). It has been suggested that the dysglycemia of IGT and additional metabolic risk factors may contribute to small nerve fibre damage in these patients.Twenty-five patients with ISFN and 12 aged-matched control subjects underwent a detailed evaluation of neuropathic symptoms, neurological deficits (Neuropathy deficit score (NDS); Nerve Conduction Studies (NCS); Quantitative Sensory Testing (QST) and Corneal Confocal Microscopy (CCM)) to quantify small nerve fibre pathology.Eight (32%) patients had IGT. Whilst all patients with ISFN had significant neuropathic symptoms, NDS, NCS and QST except for warm thresholds were normal. Corneal sensitivity was reduced and CCM demonstrated a significant reduction in corneal nerve fibre density (NFD) (P