Dual-Controlled Nanoparticles Exhibiting AND Logic
Dual-Controlled Nanoparticles Exhibiting AND Logic
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DOI：
10.1021/ja9042752
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发表时间：
2009-08-19
影响因子：
15
通讯作者：
Zink, Jeffrey I.
中科院分区：
文献类型：
--
作者：
Angelos, Sarah;Yang, Ying-Wei;Zink, Jeffrey I.
通过将两种不同类型的分子机器，光响应纳米叶轮和pH响应纳米阀连接到介孔二氧化硅纳米颗粒的不同区域来合成双控制纳米颗粒（DCNPs）。纳米叶轮基于偶氮苯衍生物，其被拴系到纳米孔内部，而纳米阀基于[2]伪轮烷，其被拴系到纳米颗粒表面。不同的分子机器通过单独的机制操作以控制加载到纳米孔中的客体分子的释放。当彼此结合使用时，获得表现为AND逻辑门的复杂可控释放系统。
Dual-controlled nanoparticles (DCNPs) are synthesized by attaching two different types of molecular machines, light-responsive nanoimpellers and pH-responsive nanovalves, to different regions of mesoporous silica nanoparticles. Nanoimpellers are based on azobenzene derivatives that are tethered to the nanopore interiors, while nanovalves are based on [2]pseudorotaxanes that are tethered to the nanoparticle surfaces. The different molecular machines operate through separate mechanisms to control the release of guest molecules that are loaded into the nanopores. When used in conjunction with one another, a sophisticated controllable release system behaving as an AND logic gate is obtained.