Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women.
Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women.
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绝经前女性血浆锌浓度与锌动力学参数之间的关联。
DOI：
10.1152/ajpendo.00533.2002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Sandstead,HaroldH
中科院分区：
文献类型：
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作者：
Yokoi,Katsuhiko;Egger,NormanG;Ramanujam,VMSadagopa;Alcock,NancyW;Dayal,HariH;Penland,JamesG;Sandstead,HaroldH
本研究的目的是测量人的血浆锌浓度与锌动力学参数之间的关系，以及锌状态与味觉敏锐度、食物频率和头发锌的关系。受试者为33名绝经前妇女，未服用口服避孕药和含铁、锌的膳食补充剂。主要结果是血浆锌浓度、基于以67Zn为示踪剂的三室哺乳动物模型的锌动力学参数、电味觉检测阈值和食物频率。较低的血浆锌显著(P<；0.01)与较小的中央和较小的外围锌池的大小，示踪剂从血浆中消失的速度较快，以及较高的转移速率常数从较小的外围池到中央池和从中央池到较大的外围池有关。血浆锌-锌动力学关系的转折点出现在9.94mol/L血浆锌/L血浆锌之间。较小的外围池大小与较低的牛肉消费频率和较高的麸皮早餐谷类食品消费频率相关。低锌血症妇女血浆锌10.7μ/L或700 ng/ml可降低对味觉神经的电刺激阈值。我们基于锌动力学的结果支持血浆锌在正常和低锌状态之间的传统界值(10.7Mol/L或700ng/ml)。
The objective of this study was to measure relationships between plasma zinc (Zn) concentrations and Zn kinetic parameters and to measure relationships of Zn status with taste acuity, food frequency, and hair Zn in humans. The subjects were 33 premenopausal women not taking oral contraceptives and dietary supplements containing iron and Zn. Main outcomes were plasma Zn concentrations, Zn kinetic parameters based on the three-compartment mammillary model using67Zn as a tracer, electrical taste detection thresholds, and food frequencies. Lower plasma Zn was significantly (P< 0.01) associated with smaller sizes of the central and the lesser peripheral Zn pools, faster disappearance of tracer from plasma, and higher transfer rate constants from the lesser peripheral pool to the central pool and from the central pool to the greater peripheral pool. The break points in the plasma Zn-Zn kinetics relationship were found between 9.94 and 11.5 μmol/l plasma Zn. Smaller size of the lesser peripheral pool was associated with lower frequency of beef consumption and higher frequency of bran breakfast cereal consumption. Hypozincemic women with plasma Zn <10.7 μmol/l or 700 ng/ml had decreased thresholds of electrical stimulation for gustatory nerves. Our results based on Zn kinetics support the conventional cutoff value of plasma Zn (10.7 μmol/l or 700 ng/ml) between normal and low Zn status.