Fast Padé Transform Accelerated CSI for Hyperpolarized MRS.
Fast Padé Transform Accelerated CSI for Hyperpolarized MRS.
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DOI：
10.18383/j.tom.2016.00154
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Laustsen C
中科院分区：
文献类型：
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作者：
Hansen ES;Kim S;Miller JJ;Geferath M;Morrell G;Laustsen C
快速Padé变换（FPT）是一种谱分析方法，可用于从截断的自由感应衰减信号重建核磁共振谱，与传统的傅里叶分析相比具有上级鲁棒性和谱分辨率。本研究的目的是显示FPT在减少超极化13 C化学位移成像（CSI）所需的扫描时间而不牺牲分辨全光谱的能力方面的实用性。用FPT处理模拟、体模和体内超极化[1- 13 C]丙酮酸CSI数据，并与传统分析方法进行比较。FPT示出了改进的稳定性和光谱分辨率截断的数据相比，快速傅立叶变换，并示出了结果，是那些基于模型的拟合方法，使13 C CSI实验中所需的采集时间减少。在不牺牲光谱分辨率的前提下，使用FPT可以将13 C CSI中光谱维度上的读出长度减少到传统傅里叶分析的2-6倍。这种增加的速度对于13 C CSI至关重要，因为T1弛豫大大限制了可用的扫描时间。此外，FPT还可以直接定量代谢物浓度，而无需常规傅立叶分析中所需的额外峰分析。
The fast Padé transform (FPT) is a method of spectral analysis that can be used to reconstruct nuclear magnetic resonance spectra from truncated free induction decay signals with superior robustness and spectral resolution compared with conventional Fourier analysis. The aim of this study is to show the utility of FPT in reducing of the scan time required for hyperpolarized 13C chemical shift imaging (CSI) without sacrificing the ability to resolve a full spectrum. Simulations, phantom, and in vivo hyperpolarized [1-13C] pyruvate CSI data were processed with FPT and compared with conventional analysis methods. FPT shows improved stability and spectral resolution on truncated data compared with the fast Fourier transform and shows results that are comparable to those of the model-based fitting methods, enabling a reduction in the needed acquisition time in 13C CSI experiments. Using FPT can reduce the readout length in the spectral dimension by 2-6 times in 13C CSI compared with conventional Fourier analysis without sacrificing the spectral resolution. This increased speed is crucial for 13C CSI because T1 relaxation considerably limits the available scan time. In addition, FPT can also yield direct quantification of metabolite concentration without the additional peak analysis required in conventional Fourier analysis.