Higher adiponectin levels predict greater weight gain in healthy women in the Nurses' Health Study.
Higher adiponectin levels predict greater weight gain in healthy women in the Nurses' Health Study.
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DOI：
10.1038/oby.2010.189
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Hu FB
中科院分区：
文献类型：
--
作者：
Hivert MF;Sun Q;Shrader P;Mantzoros CS;Meigs JB;Hu FB
脂联素和抵抗素在体重调节中的可能作用很少受到关注。我们在护士健康研究中测试了脂肪因子水平预测女性未来体重增加的假设。在1990年提供血液样本的女性中，我们研究了1063名未患糖尿病（“健康”）的女性和984名随后患糖尿病的女性。ELISA法测定总脂联素、高分子量脂联素和抵抗素水平。未患糖尿病的女性在基线时的平均体重指数（BMI）为26.3±6.0kg/m2，在4年内增加了2.0±6.1kg。患有糖尿病的女性在基线时的平均BMI为30.1±5.4kg/m2，在4年内增加了2.4±7.1kg。在未患糖尿病的女性中，在调整了年龄、BMI、体力活动、饮食和其他协变量后，较高的总脂联素和HMW基线水平与显著更高的体重增加相关：总脂联素最高五分位数的女性体重增加3.18 kg，而最低五分位数的女性体重增加0.80 kg（完全调整；趋势p <0.0001）。脂联素与随后患上糖尿病的女性体重增加没有显著关联。在随访期间，抵抗素水平与体重增加无关，无论是否患有糖尿病。我们得出结论，脂联素水平升高与健康女性体重增加有关，独立于混杂的危险因素。脂肪细胞产生的高脂联素可能是具有进一步储存脂肪能力的“健康”脂肪组织的标志。
Adiponectin and resistin’s possible roles in weight regulation have received little attention. We tested the hypothesis that adipokine levels predict future weight gain in women in the Nurses’ Health Study. Among women who provided blood samples in 1990, we studied 1063 women who did not develop diabetes (‘healthy’) and 984 women who subsequently developed diabetes. Total and high molecular weight (HMW) adiponectin and resistin levels were measured using ELISA. Women who did not developed diabetes had a mean body mass index (BMI) of 26.3±6.0kg/m2 at baseline and gained 2.0±6.1kg over 4 years. Women who developed diabetes had a mean BMI of 30.1±5.4kg/m2 at baseline, and gained 2.4±7.1kg over 4 years. In women who did not developed diabetes, higher baseline levels of total and HMW adiponectin were associated with significantly greater weight gain after adjustment for age, BMI, physical activity, diet, and other covariates: women in the highest quintile of total adiponectin gained 3.18 kg compared to women in the lowest quintile who gained 0.80 kg (fully adjusted; p for trend<0.0001). Adiponectin was not significantly associated with weight gain in women who subsequently developed diabetes. Resistin levels were not associated with weight gain in either women who did or did not developed diabetes during the follow-up. We conclude that elevated adiponectin levels are associated with higher weight gain in healthy women, independently of confounding risk factors. High adiponectin production by adipocytes might be a sign of “healthy” adipose tissue with further capacity to store fat.