How Common is Dry Mouth? Systematic Review and Meta-Regression Analysis of Prevalence Estimates
How Common is Dry Mouth? Systematic Review and Meta-Regression Analysis of Prevalence Estimates
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DOI：
10.1590/0103-6440201802302
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发表时间：
2018-12-01
影响因子：
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通讯作者：
Demarco, Flavio Fernando
中科院分区：
文献类型：
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作者：
Agostini, Bernardo Antonio;Cericato, Graziela Oro;Demarco, Flavio Fernando
本文的目的是系统地回顾文献，以估计流行病学研究中口干/低通气的总体患病率。截至2018年2月，在没有语言限制的情况下进行了电子搜索。在两名独立的审稿人应用筛选标准后，共筛选了5760篇论文，只有29篇论文被纳入综述和荟萃分析。数据从PubMed和Web of Science数据库中提取。入选标准包括来自基于观察性人群的研究的原始调查，这些研究报告了口干症的患病率或允许计算口干症和/或低通气患病率的数据。在具有特定健康状况的样本中进行的研究、文献综述、病例报告和人类学研究，作为会议或评论被排除在外。提取样本量、研究的地理位置、研究设计、研究人群的年龄、诊断方法和用于确定口干或低盐度的评价标准进行meta分析和meta回归。采用多元元回归分析探讨各研究间的异质性。口干的总体估计患病率为22.0% （95%CI 17.0-26.0%）。在仅对老年人进行的研究中观察到较高的口干患病率。尽管测量方法多种多样，但只有四分之一以上的人患有口干症，老年人的比例更高。此外，目前使用的测量方法可能高估或低估了口干症。这些发现突出了对现有的和新的临床措施进行进一步工作的必要性，并将有助于确定哪一种措施在临床和流行病学方面更可靠。
The aim of this paper is to systematically review the literature to estimate the overall prevalence of xerostomia/hyposalivation in epidemiological studies. An electronic search was carried out up to February 2018 with no language restrictions. A total of 5760 titles were screened and just twenty-nine papers were included in review and the meta-analysis after a two independently reviewers applied the selection criteria. Data were extracted from PubMed and Web of Science databases. Eligibility criteria included original investigations from observational population-based studies that reported the prevalence of xerostomia or data that allowed the calculation of prevalence of xerostomia and/or hyposalivation. Studies conducted in samples with specific health conditions, literature reviews, case reports and anthropological studies, as conferences or comments were excluded. Sample size, geographic location of the study, study design, age of the studied population, diagnosis methods, and evaluation criteria used to determine xerostomia e/or hyposalivation were extracted for meta-analysis and meta-regression. Multivariate meta-regression analysis was performed to explore heterogeneity among studies. The overall estimated prevalence of dry mouth was 22.0% (95%CI 17.0-26.0%). Higher prevalence of xerostomia was observed in studies conducted only with elderly people. Despite diverse approaches to the condition's measurement, just over one in four people suffer from xerostomia, with higher rates observed among older people. Moreover, the measurement methods used currently may over- or underestimate xerostomia. These findings highlight the need for further work on existing and new clinical measure and will be useful to determine which one is more reliable in clinical and epidemiological perspectives.