Heart failure and obesity in adults: pathophysiology, clinical manifestations and management.
Heart failure and obesity in adults: pathophysiology, clinical manifestations and management.
复制标题
DOI：
10.1007/s11897-014-0197-5
复制
发表时间：
2014-06-01
影响因子：
--
通讯作者：
Kumar, Arun
中科院分区：
文献类型：
--
作者：
Alpert, Martin A;Agrawal, Harsh;Kumar, Arun
肥胖是成人心力衰竭（HF）的危险因素和直接原因。严重肥胖会产生血流动力学改变，易导致左心室形态和功能改变，随着时间的推移，可能导致HF（肥胖性心肌病）的发展。某些神经激素和代谢异常以及心血管合并症可能会促进这一过程。实质性有目的的减肥能够逆转大多数心脏性能和形态学的改变，并可能改善肥胖性心肌病患者的功能能力和生活质量。
Obesity is both a risk factor and a direct cause of heart failure (HF) in adults. Severe obesity produces hemodynamic alterations that predispose to changes in left ventricular morphology and function, which, over time, may lend to the development of HF (obesity cardiomyopathy). Certain neurohormonal and metabolic abnormalities as well as cardiovascular co-morbidities may facilitate this process. Substantial purposeful weight loss is capable of reversing most of the alterations in cardiac performance and morphology and may improve functional capacity and quality of life in patents with obesity cardiomyopathy.