Nanotherapeutic approaches for the treatment of rheumatoid arthritis.
Nanotherapeutic approaches for the treatment of rheumatoid arthritis.
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DOI：
10.1002/wnan.157
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发表时间：
2011-11
影响因子：
8.6
通讯作者：
Pham, Christine T. N.
中科院分区：
文献类型：
--
作者：
Pham, Christine T. N.
风湿性关节炎（RA）是一种常见的炎症性疾病，其特征在于进行性骨和软骨破坏，导致严重的功能限制、寿命缩短和死亡率增加。最新的进展和新的治疗方法显著延缓了疾病进展，改善了许多患者的生活质量。然而，很少有患者在没有持续免疫抑制治疗的情况下达到或能够维持疾病缓解。此外，相当大一部分患者对目前的疗法也没有反应或最终产生耐受性。因此，持续需要开发用于治疗RA的新的治疗策略。与传统药物不同，纳米系统被设计为将治疗剂特异性地递送到炎症部位，从而避免潜在的全身性和脱靶的不良影响。它们允许研究人员考虑或重新考虑以前被认为毒性太大而不能通过全身途径递送的治疗剂。本文综述了最近的纳米技术为基础的策略，正在开发的治疗炎症性关节炎。
Rheumatoid arthritis (RA) is a common inflammatory disease characterized by progressive bone and cartilage destruction, resulting in severe functional limitations, shortened lifespan, and increased mortality rates. Recent advances and new treatment approaches have significantly delayed disease progression and improved the quality of life for many patients. Yet few patients attain or can be maintained in disease remission without continuous immunosuppressive therapy. In addition a sizable portion of patients also fails to respond or eventually develops tolerance to current therapies. Thus there is a continued need for the development of new therapeutic strategies for the treatment of RA. Unlike conventional drugs, nanosystems are designed to deliver therapeutic agents specifically to the site of inflammation, therefore avoiding potential systemic and off-target unwanted effects. They allow investigators to consider or reconsider therapeutic agents that were previously deemed too toxic to deliver through a systemic route. This article reviews recent nanotechnology-based strategies that are being developed for the treatment of inflammatory arthritis.
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