Suppression of hippocampal synaptic plasticity during slow-wave sleep
Suppression of hippocampal synaptic plasticity during slow-wave sleep
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DOI：
10.1016/0006-8993(87)90496-3
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发表时间：
1987-11
期刊：
影响因子：
2.9
通讯作者：
B. Leonard;B. McNaughton;C. A. Barnes
中科院分区：
文献类型：
--
作者：
B. Leonard;B. McNaughton;C. A. Barnes
在慢性制备的动物模型上，研究了行为状态对海马区突触长时程增强(LTE)诱导的影响。记录慢波睡眠(SWS)和清醒时齿状筋膜穿通径诱发电位和脑电。在SWS过程中，LTE被强烈抑制，这表明在睡眠周期的某些阶段，海马区的信息存储可能被失活。同样的动物在清醒时也观察到正常的LTE。
The influence of behavioral state on the induction of long-term enhancement (LTE) of hippocampal synapses was studied in chronically prepared animals. Perforant path evoked field potentials and EEG were recorded from fascia dentata during slow-wave sleep (SWS) and waking. LTE was strongly suppressed during SWS, suggesting that hippocampal information storage may be inactivated at certain phases of the sleep cycle. Normal LTE was observed in the same animals while awake.