Metabolic interactions between Toxoplasma gondii and its host.
Metabolic interactions between Toxoplasma gondii and its host.
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DOI：
10.12688/f1000research.16021.1
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Seeber, Frank
中科院分区：
文献类型：
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作者：
Blume, Martin;Seeber, Frank
弓形虫是一种专性细胞内寄生虫，属于顶复门，感染所有温血动物，包括人类。T.弓形虫可以在每一个有核宿主细胞中复制，通过协调代谢相互作用来获得关键的营养物质。本文综述了T.弓形虫与其宿主细胞，并讨论开放的问题和有前途的实验方法，将允许进一步解剖宿主-寄生虫界面和发现的方法，有效地针对速殖子和缓殖子形式的T。弓形虫，分别与急性和慢性感染有关。
Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can replicate in every nucleated host cell by orchestrating metabolic interactions to derive crucial nutrients. In this review, we summarize the current status of known metabolic interactions of T. gondii with its host cell and discuss open questions and promising experimental approaches that will allow further dissection of the host-parasite interface and discovery of ways to efficiently target both tachyzoite and bradyzoite forms of T. gondii, which are associated with acute and chronic infection, respectively.