ENHANCEMENT AND PASSIVE ACOUSTIC MAPPING OF CAVITATION FROM FLUORESCENTLY TAGGED MAGNETIC RESONANCE-VISIBLE MAGNETIC MICROBUBBLES IN VIVO
ENHANCEMENT AND PASSIVE ACOUSTIC MAPPING OF CAVITATION FROM FLUORESCENTLY TAGGED MAGNETIC RESONANCE-VISIBLE MAGNETIC MICROBUBBLES IN VIVO
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DOI：
10.1016/j.ultrasmedbio.2016.08.002
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发表时间：
2016-12-01
影响因子：
2.9
通讯作者：
Stride, Eleanor
中科院分区：
文献类型：
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作者：
Crake, Calum;Owen, Joshua;Stride, Eleanor
以前的工作表明，磁功能化的微泡在体外聚焦超声暴露下定位和增强空化活性的潜力。本研究的目的是研究磁靶向微泡促进体内空化。在小鼠异种移植模型中静脉内施用荧光标记的磁性微泡。使用0.5 MHz聚焦超声换能器在1.2-2.0 MPa的峰值负焦点压力下诱导空化，并使用B型成像和被动声标测进行实时监测。发现磁靶向与非靶向气泡相比使空化信号的振幅增加约50%。暴露后的磁共振成像表明肿瘤中有磁性纳米颗粒的沉积。磁性靶向与实验后肿瘤中荧光强度的增加类似。这些结果表明，磁靶向可能被用于改善空化介导的治疗，被动声映射可用于实时监测这一过程。（E-mail：elean.stride@ eng.ox.ac.uk）（C）2016年作者。由爱思唯尔公司出版代表世界超声波医学与生物学联合会。
Previous work has indicated the potential of magnetically functionalized microbubbles to localize and enhance cavitation activity under focused ultrasound exposure in vitro. The aim of this study was to investigate magnetic targeting of microbubbles for promotion of cavitation in vivo. Fluorescently labelled magnetic microbubbles were administered intravenously in a murine xenograft model. Cavitation was induced using a 0.5-MHz focused ultrasound transducer at peak negative focal pressures of 1.2-2.0 MPa and monitored in real-time using B-mode imaging and passive acoustic mapping. Magnetic targeting was found to increase the amplitude of the cavitation signal by approximately 50% compared with untargeted bubbles. Post-exposure magnetic resonance imaging indicated deposition of magnetic nanoparticles in tumours. Magnetic targeting was similarly associated with increased fluorescence intensity in the tumours after the experiments. These results suggest that magnetic targeting could potentially be used to improve delivery of cavitation-mediated therapy and that passive acoustic mapping could be used for real-time monitoring of this process. (E-mail: eleanor.stride@eng.ox.ac.uk) (C) 2016 The Authors. Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.