Multimodal MRI Analysis of the Corpus Callosum Reveals White Matter Differences in Presymptomatic and Early Huntington's Disease
Multimodal MRI Analysis of the Corpus Callosum Reveals White Matter Differences in Presymptomatic and Early Huntington's Disease
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DOI：
10.1093/cercor/bhr360
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发表时间：
2012-12-01
期刊：
影响因子：
3.7
通讯作者：
Sabatini, U.
中科院分区：
文献类型：
--
作者：
Di Paola, M.;Luders, E.;Sabatini, U.
最近的磁共振成像(MRI)研究表明，亨廷顿病(HD)的异常在HD早期延伸到白质(WM)束，甚至在症状前阶段。因此，胼胝体(CC)的变化可能反映HD发病的多个方面。我们招募了17名HD患者、17名HD前受试者和34名年龄匹配的健康对照组。在3T扫描仪上获得脑的三维解剖MRI和弥散张量图像。结合感兴趣区分析、基于体素的形态计量学和基于轨迹的空间统计学，我们研究了膝盖骨厚度、白质密度、各向异性分数以及径向和轴向扩散系数。与对照组相比，HD前的受试者表现出峡部减少，可能是由于髓鞘损伤。与HD前相比，HD患者表现为峡部和躯体缩小，轴突损伤局限于身体。与对照组相比，HD患者在几乎整个CC的延伸区显著减少了骨痂测量。在这个疾病阶段，髓鞘和轴突损伤都是可检测到的。补充多元回归分析显示，峡部的WM减少密度以及疾病负担评分可以预测“HD发展”指数。虽然随着疾病的进展，似乎是从后向前的方向上进行，但这一观察结果需要在未来的纵向研究中进行验证。
Recent magnetic resonance imaging (MRI) studies suggest that abnormalities in Huntington's disease (HD) extend to white matter (WM) tracts in early HD and even in presymptomatic stages. Thus, changes of the corpus callosum (CC) may reflect various aspects of HD pathogenesis. We recruited 17 HD patients, 17 pre-HD subjects, and 34 healthy age-matched controls. Three-dimensional anatomical MRI and diffusion tensor images of the brain were acquired on a 3T scanner. Combining region-of-interest analyses, voxel-based morphometry, and tract-based spatial statistics, we investigated callosal thickness, WM density, fractional anisotropy, and radial and axial diffusivities. Compared with controls, pre-HD subjects showed reductions of the isthmus, likely due to myelin damage. Compared with pre-HD subjects, HD patients showed reductions of isthmus and body, with axonal damage confined to the body. Compared with controls, HD patients had significantly decreased callosal measures in extended regions across almost the entire CC. At this disease stage, both myelin and axonal damage are detectable. Supplementary multiple regression analyses revealed that WM reduction density in the isthmus as well as Disease Burden scores allowed to predict the "HD development" index. While callosal changes seem to proceed in a posterior-to-anterior direction as the diseases progresses, this observation requires validation in future longitudinal investigations.