A surface-engineered multifunctional TiO2 based nano-layer simultaneously elevates the corrosion resistance, osteoconductivity and antimicrobial property of a magnesium alloy
A surface-engineered multifunctional TiO2 based nano-layer simultaneously elevates the corrosion resistance, osteoconductivity and antimicrobial property of a magnesium alloy
复制标题
表面工程多功能 TiO2 基纳米层同时提高镁合金的耐腐蚀性、骨传导性和抗菌性能
DOI：
10.1016/j.actbio.2019.09.008
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发表时间：
2019-11-01
影响因子：
9.7
通讯作者：
Yeung, Kelvin W. K.
中科院分区：
文献类型：
--
作者：
Lin, Zhengjie;Wu, Shuilin;Yeung, Kelvin W. K.
镁生物金属由于其生物可降解性、生物活性作用和令人满意的机械性能，在骨科应用中表现出巨大的潜力。然而，镁植入物在体内的快速腐蚀和大量氢气的析出不利于骨愈合过程，严重限制了其临床应用。受钛合金上自动形成的钝化氧化钛层优异的生物相容性和耐腐蚀性的启发，我们采用Ti和O双等离子体离子浸没注入（PIII）技术在ZK60镁基体上构建多功能TiO2基纳米层，以增强耐腐蚀性、骨传导性和抗菌性 活动。所构建的纳米层（TiO2/MgO）可以有效抑制ZK60基质的体外降解率，并且在术后8周后仍保持94%的种植体体积。在动物研究中，术后八周内，PIII治疗组周围形成大量骨组织，骨密度和小梁厚度增加。此外，PIII治疗组中新形成的骨矿化良好，其机械性能几乎恢复到周围成熟骨的水平。令人惊讶的是，在紫外线（UV）照射下，丸剂处理的样品对金黄色葡萄球菌的杀灭率高达99.31％，这主要归因于活性氧（ROS）诱导的氧化应激。我们相信，这种多功能的基于TiO2的纳米层不仅可以控制镁植入物的降解，还可以有效地调节其植入物与骨的整合。 意义声明镁植入物的快速腐蚀是骨科应用的主要问题。受钛合金上自动形成的钝化氧化钛层的生物相容性和耐腐蚀性的启发，我们在镁基体上构建了多功能TiO2/MgO纳米层，以同时实现优异的耐腐蚀性、大鼠髓内骨缺损模型中令人满意的骨传导性以及在紫外线照射下对金黄色葡萄球菌的优异抗菌活性。目前的研究结果表明，镁表面特定的 TiO2/MgO 纳米层可以实现上述三个目标，我们相信这项研究可以证明可生物降解金属在未来临床应用中的潜力。 (C) 2019 Acta Materialia Inc. 由 Elsevier Ltd 出版。保留所有权利。
Magnesium biometals exhibit great potentials for orthopeadic applications owing to their biodegradability, bioactive effects and satisfactory mechanical properties. However, rapid corrosion of Mg implants in vivo combined with large amount of hydrogen gas evolution is harmful to bone healing process which seriously confines their clinical applications. Enlightened by the superior biocompatibility and corrosion resistance of passive titanium oxide layer automatically formed on titanium alloy, we employ the Ti and O dual plasma ion immersion implantation (PIII) technique to construct a multifunctional TiO2 based nano-layer on ZK60 magnesium substrates for enhanced corrosion resistance, osteoconductivity and antimicrobial activity. The constructed nano-layer (TiO2/MgO) can effectively suppress degradation rate of ZK60 substrates in vitro and still maintain 94% implant volume after post-surgery eight weeks. In animal study, a large amount of bony tissue with increased bone mineral density and trabecular thickness is formed around the PIII treated group in post-operation eight weeks. Moreover, the newly formed bone in the PIII treated group is well mineralized and its mechanical property almost restores to the level of that of surrounding mature bone. Surprisingly, a remarkable killing ratio of 99.31% against S. aureus can be found on the Pill treated sample under ultra-violet (UV) irradiation which mainly attributes to the oxidative stress induced by the reactive oxygen species (ROS). We believe that this multifunctional TiO2 based nano-layer not only controls the degradation of magnesium implant, but also regulates its implant-to-bone integration effectively.Statement of significanceRapid corrosion of magnesium implants is the major issue for orthopaedic applications. Inspired by the biocompatibility and corrosion resistance of passive titanium oxide layer automatically formed on titanium alloy, we construct a multifunctional TiO2/MgO nanolayer on magnesium substrates to simultaneously achieve superior corrosion resistance, satisfactory osteoconductivity in rat intramedullary bone defect model and excellent antimicrobial activity against S. aureus under UV irradiation. The current findings suggest that the specific TiO2/MgO nano-layer on magnesium surface can achieve the three objectives aforementioned and we believe this study can demonstrate the potential of biodegradable metals for future clinical applications. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.