Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women
Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women
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DOI：
10.1093/jn/132.9.2609
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发表时间：
2002-09-01
影响因子：
4.2
通讯作者：
Dallal, GE
中科院分区：
文献类型：
--
作者：
Booth, SL;Lichtenstein, AH;Dallal, GE
比较绿色蔬菜和油类对叶绿醌的吸收的研究得出了模棱两可的结果。为了解决评估叶绿醌吸收方法的差异，对18名年轻（20-40岁）和18名年长（60-80岁）的男性和女性进行了24小时的吸收研究，作为一项更大的代谢研究的一部分，该研究比较了西兰花和叶绿醌强化油（分别为377 +/- 46和417 +/- 45马克杯/天）对维生素K状态的影响。吸收被定义为血浆叶绿醌浓度的24小时曲线下面积（AUC）（未调整和调整甘油三酯浓度）。食用叶绿醌强化油日粮后，血浆叶绿醌浓度的平均AUC（未调整和调整）显著高于食用西兰花日粮（P < 0.001）。然而，两种治疗在24小时空腹血浆叶绿醌浓度上没有差异。虽然经甘油三酯校正后的血浆叶绿醌AUC没有年龄差异，但老年人在0和24小时的血浆叶绿醌浓度（未校正和校正）明显高于年轻人（P < 0.001）。这些数据强调，使用不同的方法来评估维生素K的吸收可能会得出不同的结论。
Studies that have compared the absorption of phylloquinone from green vegetables and oils have equivocal results. To address differences in approaches used to assess absorption of phylloquinone, a 24-h absorption study was conducted in 18 younger (20-40 y) and 18 older (60-80 y) men and women as part of a larger metabolic study that compared changes in vitamin K status in response to broccoli and phylloquinone-fortified oil (377 +/- 46 and 417 +/- 45 mug/d respectively). Absorption was defined as the 24-h area under the curve (AUC) for plasma phylloquinone concentrations (both unadjusted and adjusted for triglyceride concentrations). The mean AUC for plasma phylloquinone concentrations (both unadjusted and adjusted) were significantly greater after consumption of the phylloquinone-fortified oil diet compared with the broccoli diet (P < 0.001). However, there were no differences between the two treatments in 24-h fasting plasma phylloquinone concentrations. Although there were no age differences in the AUC for plasma phylloquinone, adjusted for triglycerides, older adults had significantly higher plasma phylloquinone concentrations (both unadjusted and adjusted) at 0 and 24 h than the younger adults (P < 0.001). These data emphasize that the use of different approaches for the assessment of vitamin K absorption can result in disparate conclusions.