Epigenome-wide association study of BMI in Black populations from InterGEN and GENOA.
Epigenome-wide association study of BMI in Black populations from InterGEN and GENOA.
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DOI：
10.1002/oby.23589
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发表时间：
2023-01
期刊：
影响因子：
6.9
通讯作者：
Sun, Yan, V
中科院分区：
文献类型：
--
作者：
Taylor, Jacquelyn Y.;Huang, Yunfeng;Zhao, Wei;Wright, Michelle L.;Wang, Zeyuan;Hui, Qin;Potts-Thompson, Stephanie;Barcelona, Veronica;Prescott, Laura;Yao, Yutong;Crusto, Cindy;Kardia, Sharon L. R.;Smith, Jennifer A.;Sun, Yan, V
肥胖症是地球仪的一个重要的公共卫生问题。调查与肥胖和肥胖相关疾病相关的表观遗传机制的研究已经确定了可能导致细胞失调的差异，这些差异加速了疾病的发展。然而，很少有研究包括黑人妇女，谁的经验最高的发病率肥胖和早发性心脏代谢紊乱。在两个黑人群体中，使用850 K Illumina EPIC BeadChip检查BMI与表观基因组全DNA甲基化（DNAm）的关联。（遗传和心理因素对血压的代际影响[InterGEN]，n = 239;和动脉病遗传流行病学网络[GENOA]研究，n = 961），使用针对批次效应、细胞类型异质性调整的线性混合效应回归模型，人口分层和混杂因素。InterGEN发现队列的横截面分析确定了28个与BMI显著相关的DNAm位点，其中24个先前未报告。其中，17个重复使用GENOA研究。此外，包括InterGEN和GENOA队列的Meta分析确定了658个与BMI相关的DNAm位点，错误发现率< 0.05。在对黑人女性的Meta分析中，我们确定了628个与BMI显著相关的DNA位点。使用更严格的Bonferroni校正p值0.05的显著性阈值，从性别和仅女性Meta分析中分别确定了65和61个与BMI相关的DNA m位点。这项研究表明，BMI与女性中DNAm的差异有关，这些差异可以通过从两个队列的黑人人群中的唾液（发现）和外周血（复制）样本中提取的DNA来确定。
Obesity is a significant public health concern across the globe. Research investigating epigenetic mechanisms related to obesity and obesity‐associated conditions has identified differences that may contribute to cellular dysregulation that accelerates the development of disease. However, few studies include Black women, who experience the highest incidence of obesity and early onset of cardiometabolic disorders. The association of BMI with epigenome‐wide DNA methylation (DNAm) was examined using the 850K Illumina EPIC BeadChip in two Black populations (Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure [InterGEN], n = 239; and The Genetic Epidemiology Network of Arteriopathy [GENOA] study, n = 961) using linear mixed‐effects regression models adjusted for batch effects, cell type heterogeneity, population stratification, and confounding factors. Cross‐sectional analysis of the InterGEN discovery cohort identified 28 DNAm sites significantly associated with BMI, 24 of which had not been previously reported. Of these, 17 were replicated using the GENOA study. In addition, a meta‐analysis, including both the InterGEN and GENOA cohorts, identified 658 DNAm sites associated with BMI with false discovery rate < 0.05. In a meta‐analysis of Black women, we identified 628 DNAm sites significantly associated with BMI. Using a more stringent significance threshold of Bonferroni‐corrected p value 0.05, 65 and 61 DNAm sites associated with BMI were identified from the combined sex and female‐only meta‐analyses, respectively. This study suggests that BMI is associated with differences in DNAm among women that can be identified with DNA extracted from salivary (discovery) and peripheral blood (replication) samples among Black populations across two cohorts.
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DOI：
10.1038/s41366-020-0646-z
发表时间：
2020-11
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Crocker KC;Domingo-Relloso A;Haack K;Fretts AM;Tang WY;Herreros M;Tellez-Plaza M;Daniele Fallin M;Cole SA;Navas-Acien A
通讯作者：
Navas-Acien A
影响因子：
168.9
作者：
Dick, Katherine J.;Nelson, Christopher P.;Samani, Nilesh J.
通讯作者：
Samani, Nilesh J.
影响因子：
--
作者：
Fortin, Jean-Philippe;Fertig, Elana;Hansen, Kasper
通讯作者：
Hansen, Kasper
影响因子：
4.6
作者：
He, Fan;Berg, Arthur;Liao, Duanping
通讯作者：
Liao, Duanping
影响因子：
4.9
作者：
Campanella, Gianluca;Gunter, Marc J.;Chadeau-Hyam, Marc
通讯作者：
Chadeau-Hyam, Marc