The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency.
The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency.
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潜伏相关的核抗原是Kaposi肉瘤相关的疱疹病毒潜伏期的多功能蛋白。
DOI：
10.2217/fmb.11.137
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发表时间：
2011-12
影响因子：
3.1
通讯作者：
Kaye KM
中科院分区：
文献类型：
--
作者：
Ballestas ME;Kaye KM
潜伏期相关核抗原(LANA)由Kaposi肉瘤相关疱疹病毒(KSHV)开放阅读框73编码。LANA在KSHV潜伏感染的细胞中表达，包括肿瘤细胞，如原发渗出性淋巴瘤、KS和多中心Castleman病。潜伏感染的细胞有多个共价闭合的环状KSHV基因组的染色体外拷贝(Episome)，这些拷贝稳定地维持在增殖细胞中。拉娜最具特色的功能是调停圣公会的坚持。它通过将末端重复序列与染色体基质结合来实现这一点，从而确保在每次细胞分裂时进行表型复制，并在有丝分裂后有效地将DNA分离到子核。为了实现这些功能，LANA与不同的宿主细胞蛋白结合，包括染色质相关蛋白和参与DNA复制的蛋白。除了Episome维持外，LANA还具有转录调控作用，并影响细胞生长。LANA通过与不同的细胞蛋白质相互作用来发挥这些功能。
Latency-associated nuclear antigen (LANA) is encoded by the Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 73. LANA is expressed during latent KSHV infection of cells, including tumor cells, such as primary effusion lymphoma, KS and multicentric Castleman’s disease. Latently infected cells have multiple extrachromosomal copies of covalently closed circular KSHV genomes (episomes) that are stably maintained in proliferating cells. LANA’s best characterized function is that of mediating episome persistence. It does so by binding terminal repeat sequences to the chromosomal matrix, thus ensuring episome replication with each cell division and efficient DNA segregation to daughter nuclei after mitosis. To achieve these functions, LANA associates with different host cell proteins, including chromatin-associated proteins and proteins involved in DNA replication. In addition to episome maintenance, LANA has transcriptional regulatory effects and affects cell growth. LANA exerts these functions through interactions with different cell proteins.