corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae
corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae
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DOI：
10.1007/s004380100572
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发表时间：
2001-12-01
影响因子：
3.1
通讯作者：
Peronnet, F
中科院分区：
文献类型：
--
作者：
Lopez, A;Higuet, D;Peronnet, F
在果蝇身上。片段的同源性由同源异型基因(Hox)的特定表达决定。HOX的表达模式首先由GAP和配对规则基因启动，然后由多梳基因(Pc-G)和三胸基因(Trx-G)维持。由于突变体表现出同源异型转化，因此corto基因可能是HOX基因的调节因子。我们在这里表明，除了先前报道的与Zust、Poycomb和多同源染色体的Pc-G基因增强子的遗传交互作用外，corto基因的突变还增强了多性别梳子、多梳状梳子和中腿性别梳子的异性梳子表型。Corto还与一些trx-G基因(ashl、kismet、kohtalo)存在遗传上的相互作用。莫伊拉、OSA、类三胸和Vha55)。与TRX-G基因的相互作用导致表型显示在翅膀、前胸后或胸部机械感觉刷毛中。此外，我们还分析了Hox基因Ubx在corto突变体中的调控。我们的结果为Corto在三龄幼虫中维持Ubx表达的前缘提供了证据。我们认为这种调节是通过与Pc-G和Trx-G基因的产物相互作用来完成的。
In Drosophila melanogaster. segment identity is determined by specific expression of homeotic genes (Hox). The Hox expression pattern is first initiated by gap and pair-rule genes and then maintained by genes of the Polycomb-group (Pc-G) and the trithorax-group (trx-G). The corto gene is a putative regulator of the Hox genes since mutants exhibit homeotic transformations. We show here that, in addition to previously reported genetic interactions with the Pc-G genes Enhancer of zeste, Poycomb and polyhomeotic, mutations in corto enhance the extra-sex-comb phenotype of multi sex combs, Polycomb-like and Sex combs on midleg. corto also genetically interacts with a number of trx-G genes (ashl, kismet, kohtalo. moira, osa, Trithorax-like and Vha55). The interactions with genes of the trx-G lead to phenotypes displayed in the wing, in the postpronotum or in the thoracic mechanosensory bristles. In addition, we analyzed the regulation of the Hox gene Ultrabithorax (Ubx) in corto mutants. Our results provide evidence that corto maintains the anterior border of Ubx expression in third-instar larvae. We suggest that this regulation is accomplished through an interaction with the products of the Pc-G and trx-G genes.