Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.
Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.
复制标题
早产婴儿的脑损伤：破坏性和发育障碍的复杂汞合金。
DOI：
10.1016/s1474-4422(08)70294-1
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发表时间：
2009-01
期刊：
影响因子：
48
通讯作者：
Volpe, Joseph J.
中科院分区：
文献类型：
--
作者：
Volpe, Joseph J.
早产儿脑损伤在公共卫生方面具有极其重要的意义，因为有大量此类婴儿存活下来却伴有严重的神经发育残疾，包括严重的认知缺陷和运动障碍。这种脑损伤通常被认为主要由脑室周围白质软化症（PVL）组成，这是一种独特的脑白质损伤形式。重要的新研究表明，PVL经常伴有神经元/轴突疾病，影响脑白质、丘脑、基底神经节、大脑皮层、脑干和小脑。这种PVL和神经元/轴突疾病的组合非常独特，足以被称为“早产儿脑病”。本综述的论点是，早产儿脑病是原发性破坏性疾病以及继发性成熟和营养障碍的复杂混合体。本综述整合了关于人类早产儿期脑损伤和脑发育的新见解的奇妙融合。
Brain injury in premature infants is of enormous public health importance because of the large number of such infants who survive with serious neurodevelopmental disability, including major cognitive deficits and motor disability. This type of brain injury is generally thought to consist primarily of periventricular leukomalacia (PVL), a distinctive form of cerebral white matter injury. Important new work shows that PVL is frequently accompanied by neuronal/axonal disease, affecting the cerebral white matter, thalamus, basal ganglia, cerebral cortex, brain stem, and cerebellum. This constellation of PVL and neuronal/axonal disease is sufficiently distinctive to be termed “encephalopathy of prematurity”. The thesis of this Review is that the encephalopathy of prematurity is a complex amalgam of primary destructive disease and secondary maturational and trophic disturbances. This Review integrates the fascinating confluence of new insights into both brain injury and brain development during the human premature period.