CENTRAL MECHANISM OF VASOPRESSIN‐INDUCED CHANGES IN ANTIDIURETIC HORMONE RELEASE
CENTRAL MECHANISM OF VASOPRESSIN‐INDUCED CHANGES IN ANTIDIURETIC HORMONE RELEASE
复制标题
加压素引起的抗利尿激素释放变化的中心机制
DOI：
10.1111/j.1476-5381.1977.tb16750.x
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发表时间：
1977
影响因子：
7.3
通讯作者：
Y. Srivastava
中科院分区：
文献类型：
--
作者：
K. Bhargava;V. Kulshrestha;Y. Srivastava
1侧脑室注射（i. c. v.）在氯醛糖麻醉的犬中给予血管加压素（0.001-1.0 u），导致尿流量呈剂量依赖性增加，同时颈静脉血中抗利尿激素（ADH）水平降低。2高剂量加压素（1.5-2.0 u，i. c. v.）另一方面具有抗利尿作用，并使血液ADH水平升高。3预处理（i. c. v.）β肾上腺素受体拮抗剂完全阻断了低剂量加压素（i. c. v.）但不影响用高剂量获得的抗利尿反应。4重复给予加压素（1.0 u，i. c. v.）诱导快速耐受;用丁苯那嗪消耗中枢儿茶酚胺显著抑制加压素诱导的利尿反应。5得出结论，脑室内加压素诱导的ADH分泌变化是通过中枢神经系统中儿茶酚胺的释放介导的。
1 Intracerebroventricularly (i.c.v.) administered vasopressin (0.001–1.0 u) in dogs anaesthetized with chloralose produced a dose‐dependent increase in urine flow with a concomitant decrease in the levels of antidiuretic hormone (ADH) in jugular vein blood. 2 Higher doses of vasopressin (1.5–2.0 u, i.c.v.) on the other hand had an antidiuretic effect and produced an increase in blood ADH level. 3 Pretreatment (i.c.v.) with a β‐adrenoceptor antagonist completely blocked the diuretic response of low doses of vasopressin (i.c.v.) but did not influence the antidiuretic response obtained with high doses. 4 Repeated administration of vasopressin (1.0 u, i.c.v.) induced tachyphylaxis; central catecholamine depletion with tetrabenazine significantly inhibited the vasopressin‐induced diuretic response. 5 It is concluded that intracerebroventricular vasopressin‐induced changes in ADH secretion are mediated through the release of catecholamines in the central nervous system.